Release of a model protein from biodegradable self assembled films for surface delivery applications.

Journal of Controlled Release : Official Journal of the Controlled Release Society
Mara L MacdonaldPaula T Hammond

Abstract

Layer-by-layer (LbL) films have multiple features that make them attractive for drug delivery, including the potential to sequentially deliver growth factors from implantable medical devices or tissue engineering scaffolds. To date, however, characterization has been lacking for protein delivery from such films. Here, LbL polyelectrolyte films constructed with the model protein lysozyme and a hydrolytically degradable and biocompatible synthetic polycation are characterized. Milligram/cm(2) scale linear or power law release profiles can be achieved over 2 to 34 days, and control over loading and release are demonstrated through parameters such as tuning the degradability of the synthetic polycation, changing the number of layers used, or changing the polysaccharide polyanion. Functionality is maintained at nearly 100%, underscoring mild processing conditions apt to preserve fragile protein function. LbL films thus have promise as a tool for exploring protein modulation of the interaction between implanted surfaces and the cells they contact.

Citations

Aug 10, 2010·Biomacromolecules·Mara L MacdonaldPaula T Hammond
May 18, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Ryan M FlessnerDavid M Lynn
Apr 8, 2010·The Review of Scientific Instruments·Daniel GamboaJaime C Grunlan
May 27, 2014·Biotechnology Advances·Lara Yildirimer, Alexander M Seifalian
Jul 28, 2009·Journal of Materials Science. Materials in Medicine·Sabine PonaderEmeka Nkenke
Jul 28, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Byeong-Su KimPaula T Hammond
Sep 24, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Anita ShuklaPaula T Hammond
Jun 21, 2011·Advanced Drug Delivery Reviews·Svetlana Pavlukhina, Svetlana Sukhishvili
May 11, 2011·Advanced Drug Delivery Reviews·Hua Ai
Jan 25, 2011·Journal of Colloid and Interface Science·Galina LauferJaime C Grunlan
Oct 12, 2010·Journal of Colloid and Interface Science·Zhangliang GuiQiang Zhao
Nov 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Brian Amsden
Mar 3, 2011·Advanced Materials·Nishit DoshiSamir Mitragotri
Dec 3, 2010·Macromolecular Bioscience·Gabriela V MartinsNatália M Alves
Aug 18, 2010·Small·Alisa L BeckerFrank Caruso
Oct 7, 2010·Small·Anita ShuklaPaula T Hammond
Jun 8, 2011·Biomaterials·Nisarg J ShahPaula T Hammond
Jul 19, 2011·Biomaterials·Raymond E SamuelPaula T Hammond
Jun 10, 2011·Journal of Colloid and Interface Science·Zhangliang GuiWendan Sun
Nov 26, 2010·Chemical Communications : Chem Comm·Ryan M FlessnerDavid M Lynn
Apr 27, 2016·Advanced Healthcare Materials·Bahar ErgünNermin Seda Kehr

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