Release of Amino- or Carboxy-Containing Compounds Triggered by HOCl: Application for Imaging and Drug Design

Angewandte Chemie
Peng WeiTao Yi

Abstract

The overproduction of HOCl is highly correlated with diseases such as atherosclerosis, rheumatoid arthritis, and cancer. Whilst acting as a marker of these diseases, HOCl might also be used as an activator of prodrugs or drug delivery systems for the treatment of the corresponding disease. In this work, a new platform of HOCl probes has been developed that integrates detection, imaging, and therapeutic functions. The probes can detect HOCl, using both NIR emission and the naked eye in vitro, with high sensitivity and selectivity at ultralow concentrations (the detection limit is at the nanomolar level). Basal levels of HOCl can be imaged in HL-60 cells without special stimulation. Moreover, the probes provided by this platform can rapidly release either amino- or carboxy-containing compounds from prodrugs, during HOCl detection and imaging, to realize a therapeutic effect.

References

Feb 9, 1989·The New England Journal of Medicine·S J Weiss
Dec 9, 2003·Amino Acids·C L HawkinsM J Davies
Nov 1, 2008·Journal of the American Chemical Society·Ying ZouChunhui Huang
Jan 22, 2009·Chemistry : a European Journal·Weiying LinWen Tan
Mar 30, 2010·European Journal of Haematology·Antonio Palumbo, S Vincent Rajkumar
Mar 9, 2012·Theranostics·Ki Young ChoiXiaoyuan Chen
May 1, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Lidia Gebicka, Ewa Banasiak
Jan 31, 2013·ChemMedChem·Carlo BallatoreAmos B Smith
Mar 7, 2013·Journal of the American Chemical Society·Sukhendu MaitiJong Seung Kim
Sep 5, 2013·Journal of the American Chemical Society·Bong Jin HongSonBinh T Nguyen
Mar 13, 2014·Nature Communications·Ran MoZhen Gu
Apr 2, 2014·Chemical Communications : Chem Comm·Luyan MengTao Yi
May 27, 2015·Chemical Communications : Chem Comm·Wei ZhangBo Tang
Apr 15, 2016·Therapeutic Delivery·Okhil K NagJames B Delehanty
Jan 21, 2017·Advanced Science·Gurusamy SaravanakumarWon Jong Kim
May 2, 2017·Journal of the American Chemical Society·Li WuDaniel T Chiu
Jul 5, 2016·Bioengineering & Translational Medicine·Jing Liang, Bin Liu
Mar 27, 2018·Chemical Communications : Chem Comm·Changyu ZhangLong Yi
Apr 6, 2018·Chemical Science·Peng WeiTao Yi
Jun 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Cheng-Cheng SongZi-Chen Li
Jul 28, 2015·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Faheem MuhammadGuangshan Zhu

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Citations

May 11, 2020·Bioorganic & Medicinal Chemistry Letters·Hai-Ge WeiXiao-Dong Zhao
Feb 4, 2021·Journal of Fluorescence·Qiang ZhangZhanxian Li
Nov 9, 2020·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Tian-Ran WangShi-Li Shen
Apr 6, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xiaowen ZhangBin Liu
Apr 30, 2021·Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy·Xiaowen ZhangBin Liu
Oct 12, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Xiao-Bo WangYan-Chao Wu

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