Release of amphotericin B from delivery systems and its action against fungal and mammalian cells

Journal of Drug Targeting
P LegrandJ Bolard

Abstract

Spectroscopic studies of four amphotericin B (AmB) lipid preparations--small negatively charged unilamellar vesicles "AmBisome", positively charged oligolamellar liposomes "Ampholiposomes", AmB Lipid Complex "L-AmpB33"--and AmB association with gamma cyclodextrin demonstrated that the composition of drug delivery system directly influences AmB organization. The aggregation state and release in external medium of AmB was monitored by circular dichroism and UV-visible absorption. AmB short-term activity against Candida albicans (K+ leakage) was found to be correlated with the amount of free AmB released from lipid preparations. These data seem to indicate that lipid composition influences anti-Candida albicans activity, by modulation of AmB binding to lipids.

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Citations

Jun 22, 2014·Biochimie·T T H PhamG Barratt
Jan 15, 2016·Drug Development and Industrial Pharmacy·Phatsawee JansookThorsteinn Loftsson
Oct 27, 2007·Pharmaceutical Development and Technology·J-U JunghannsB P G L Damasceno
Jul 30, 2005·Journal of Drug Targeting·J A Sánchez-BruneteJ J Torrado
Sep 26, 2007·Journal of Pharmaceutical Sciences·J J TorradoS Torrado-Santiago
May 30, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·H Van de VenA Ludwig
Nov 22, 2011·Biochemical and Biophysical Research Communications·Amitabha Chattopadhyay, Md Jafurulla
Oct 10, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Kosuke ShimizuNaoto Oku
Jul 21, 2012·International Journal of Pharmaceutics·Mélanie FauvelGillian Barratt
May 19, 2006·International Journal of Antimicrobial Agents·Pranatharthi Chandrasekar
Jul 7, 2016·Antimicrobial Agents and Chemotherapy·B Eleazar Cohen
Feb 1, 2006·The Journal of Antimicrobial Chemotherapy·Koji TakemotoYoshihito Niki

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