PMID: 6028491Aug 1, 1967Paper

Release of an endogenous pyrogen in vitro from rabbit mononuclear cells

The Journal of Experimental Medicine
E AtkinsL Francis

Abstract

The capacity of rabbit mononuclear cells to release an endogenous pyrogen (EP) in vitro has been studied. After incubation with tuberculin, preparations of predominantly monocytic cells, derived from the respiratory passages of the lungs of rabbits sensitized with BCG, were activated to release EP. Pyrogen production occurred more slowly with lung monocytes than with blood leukocytes of similarly sensitized rabbits and 9 to 10 hr incubation in a fully supportive medium was required to produce clear-cut results. As previously reported with blood leukocytes, mononuclear cells from the lungs of normal animals were also activated by tuberculin but to a lesser degree than were those from specifically sensitized rabbits. Under a variety of conditions, mononuclear cells from either spleen or lymph nodes of the same sensitized rabbits failed to release detectable amounts of pyrogen when incubated with tuberculin in vitro but were activated in a majority of instances when phagocytosis of heat-killed staphylococci was used as the stimulus. Release of pyrogen from lung monocytes appears to be an active process that is both temperature-dependent and requires protein synthesis. Neither serum antibody nor complement appears to play a role in...Continue Reading

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May 4, 1967·The New England Journal of Medicine·P Bodel, E Atkins
Mar 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·P Bodel, E Atkins
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Citations

Mar 1, 1980·Biulleten' eksperimental'noĭ biologii i meditsiny·A V SorokinO M Efremov
Mar 1, 1980·Biulleten' eksperimental'noĭ biologii i meditsiny·L G Agasarov
Jan 1, 1969·Archiv für die gesamte Virusforschung·K GrossgebauerR Kuechler
Aug 1, 1983·Agents and Actions·C A Dinarello
Jan 1, 1982·Pharmacology & Therapeutics·R Hellon, Y Townsend
Sep 1, 1990·Veterinary Immunology and Immunopathology·P C Canning, P E Baker
Feb 1, 1984·Brain Research Bulletin·W L VealeW D Ruwe
Oct 1, 1970·The New England Journal of Medicine·R B HornickM J Snyder
Mar 16, 1978·The New England Journal of Medicine·C A Dinarello, S M Wolff
Aug 1, 1968·The Journal of Experimental Medicine·R K Root, S M Wolff
Dec 1, 1968·The Journal of Experimental Medicine·N H Ruddle, B H Waksman
Oct 1, 1969·The Journal of Experimental Medicine·D L Bornstein, J W Woods
Jan 1, 1970·The Journal of Experimental Medicine·D M MooreW B Wood
Apr 1, 1970·The Journal of Experimental Medicine·J J NordlundS M Wolff
Aug 1, 1972·The Journal of Experimental Medicine·M J Chusid, E Atkins
Oct 1, 1974·The Journal of Experimental Medicine·P Bodel
Mar 1, 1977·The Journal of Experimental Medicine·P Bodel, H Miller
Oct 1, 1969·Annals of Surgery·A S Hermreck, A P Thal
Sep 1, 1968·British Journal of Pharmacology·C H Cashin, C E Heading
Dec 1, 1990·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·P De ManC Svanborg
Jun 13, 1970·British Medical Journal·G S Panayi
Jan 1, 1968·The Journal of Clinical Investigation·P Bodel, M Dillard
Mar 1, 1991·Kidney International·C SvanborgT Sandberg
May 1, 1982·The American Journal of Medicine·C A Dinarello, S M Wolff
Jan 1, 1982·Annals of the New York Academy of Sciences·D L Bornstein
Feb 1, 1980·The Journal of Pathology·J M Papadimitriou, T A Robertson
May 1, 1992·The Annals of Thoracic Surgery·J ButlerG M Rocker
Nov 1, 1989·Infection and Immunity·P de ManC Svanborg Edén
Jun 1, 1979·Microbiological Reviews·N J Roberts

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