Release of Antibodies and Cytokines from B Cells

Methods in Molecular Biology
Shuang Liu

Abstract

Autoreactive B cells play a critical role in rheumatoid arthritis. These cells differentiate into long-living memory B cells and autoantibody-producing plasma cells and also present autoantigens to T cells to amplify misdirected immune responses. The therapeutic benefit of B-cell-deleting therapies suggests that B cells are emerging as important factors in the pathogenesis of RA. Aiming at evaluation of the function of B cells, which are usually derived from peripheral blood of RA patients and healthy donors, it is possible to conduct a series of experiments, such as in vitro assessment of antibody production and BCR-mediated cytokine release. These techniques can also be applied for in vivo application.

Citations

Apr 23, 2021·Oral Diseases·Julieta Saraí Becerra-RuizJuan Manuel Guzmán-Flores

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