Release of beta-endorphin by caffeic acid to lower plasma glucose in streptozotocin-induced diabetic rats

Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme
J T ChengT Yamamoto

Abstract

The role of alpha 1A -adrenoceptors in the regulation of opioid secretion from the adrenal glands of streptozotocin-induced diabetic rats (STZ-diabetic rats) was examined in an attempt to determine the mechanism of plasma glucose-lowering action of caffeic acid. In agreement with a previous report, we showed that caffeic acid produced a dose-dependent lowering of the plasma glucose concentration in STZ-diabetic rats along with an increase of plasma beta-endorphin-like immunoreactivity (BER). These actions of caffeic acid were abolished by pretreatment with WB 4101 or RS 17 056 at doses sufficient to block alpha 1A -adrenoceptors. In addition, naloxone and naloxonazine at doses effective for blocking opioid micro -receptors abolished the plasma glucose-lowering action of caffeic acid. Also, unlike that in wild-type diabetic mice, caffeic acid failed to produce a plasma glucose lowering effect in opioid micro -receptor knockout diabetic mice. We observed that caffeic acid could enhance BER release from isolated rat adrenal medulla in a concentration-dependent manner; inhibitors of alpha 1A -adrenoceptors such as WB 4101 and RS 1705 abolished this action. Investigations of the signal pathways further supported that activation of a...Continue Reading

Citations

Nov 28, 2012·Applied Microbiology and Biotechnology·Haoran Zhang, Gregory Stephanopoulos
Dec 20, 2008·Evidence-based Complementary and Alternative Medicine : ECAM·I M Liu, J T Cheng
Apr 25, 2015·Behavioral and Brain Functions : BBF·Guojuan LiangJunqing Yang
Apr 29, 2006·The Journal of Pharmacology and Experimental Therapeutics·Un Ju JungMyung-Sook Choi
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Nada OršolićMaja Jazvinšćak Jembrek
Dec 2, 2004·Peptides·Richard J Bodnar, Gad E Klein
May 30, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Hamideh VahidAhmad Ghorbani

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