Release of Ciprofloxacin and Moxifloxacin From Daily Disposable Contact Lenses From an In Vitro Eye Model

Investigative Ophthalmology & Visual Science
Magdalena BajgrowiczLyndon Jones

Abstract

To analyze the release of two fluoroquinolones, ciprofloxacin and moxifloxacin, from conventional hydrogel (CH) and silicone hydrogel (SH) daily disposable contact lenses (CLs), comparing release from a fixed-volume vial and a novel in vitro eye model. Four CH CLs (nelfilcon A, omafilcon A, etafilcon A, ocufilcon B) and three SH CLs (somofilcon A, narafilcon A, delefilcon A) were used. The lenses were incubated in drug solutions for 24 hours. After the incubation period, the lenses were placed in two release conditions: (1) a vial containing 4.8 mL PBS for 24 hours and (2) an in vitro eye model with a flow rate at 4.8 mL over 24 hours. Release in the vial for both drugs was rapid, reaching a plateau between 15 minutes and 2 hours for all lenses. In contrast, under physiological flow conditions, a constant and slow release was observed over 24 hours. The amounts of ciprofloxacin released from the lenses ranged between 49.6 ± 0.7 and 62.8 ± 0.3 μg per lens in the vial, and between 35.0 ± 7.0 and 109.0 ± 5.0 μg per lens in the eye model. Moxifloxacin release ranged from 24.0 ± 4.0 to 226.0 ± 2.0 μg per lens for the vial, and between 13.0 ± 2.0 and 151.0 ± 10.0 μg per lens in the eye model. In both systems and for both drugs, HEMA-...Continue Reading

Citations

Oct 17, 2018·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Chau-Minh PhanLyndon Jones
Sep 26, 2017·Eye & Contact Lens·Siwei ZhouRobert M Q Shanks
Aug 31, 2018·Journal of Biomaterials Science. Polymer Edition·Chau-Minh PhanLyndon Jones
Feb 26, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Chau-Minh PhanLyndon W Jones
Dec 8, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Chau-Minh PhanLyndon W Jones
Sep 19, 2019·Journal of Biomaterials Science. Polymer Edition·Ryan R HorneWilliam G Pitt
Sep 25, 2017·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Alex Hui
Sep 20, 2019·Translational Vision Science & Technology·Chau-Min PhanLyndo Jones
Dec 17, 2018·Journal of Controlled Release : Official Journal of the Controlled Release Society·Karolina MulasMarcin Sobczak
Mar 7, 2021·Pharmaceutics·Chau-Minh PhanLyndon Jones
Aug 28, 2020·Acta Biomaterialia·Xin FanAllan E David
Mar 30, 2021·Contact Lens & Anterior Eye : the Journal of the British Contact Lens Association·Lyndon JonesMark Willcox

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