Release of contraceptive steroids from sustained release dosage forms and resulting plasma levels

Contraception
H A NashT M Jackanicz

Abstract

The correlations of plasma levels of levonorgestrel, megestrol acetate and norgestrienone with the doses delivered from subdermal implants and contraceptive rings have been examined. Differences in plasma levels as large as three-fold between different subjects receiving nearly identical doses were observed with all three steroids. The relative plasma levels seen from one subject to another showed high consistency over time. Part of the explanation may lie in differing levels of sex hormone binding globulin, but additional factors must be operative since megestrol acetate binds only weakly with this carrier.

Citations

Aug 1, 1991·The Australian & New Zealand Journal of Obstetrics & Gynaecology·M Cooper
Sep 23, 2008·Expert Review of Medical Devices·G BenagianoManuela Farris
Aug 1, 1987·American Journal of Reproductive Immunology and Microbiology : AJRIM·L W Keisler, S E Walker

Related Concepts

Vaginal Shield
Dose-Response Relationship, Drug
Megestrol
Postinor
R2010
Norpregnatrienes

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