PMID: 6979261May 1, 1982Paper

Release of creatine kinase from frog muscle by osmotic changes

The American Journal of Physiology
G Suarez-Kurtz

Abstract

The rate of creatine kinase (CK) release from isolated frog extensor longus digiti IV ("toe") muscle increased on transfer from the control Ringer solution (referred to as 1.0 T) to a hyperosmotic solution (1.0 T plus 400 mM glycerol) or to hypertonic solutions (1.5-2.5 T) prepared by addition of NaCl or sucrose to 1.0 T. On return to 1.0 T, CK release rate was further elevated, reaching peak values (14.4- and 12-fold above the basal value, respectively, with the glycerol treatment and with solution 2.5 T) within 10-15 min and declining subsequently toward base line. Although the stimulation of CK release by changes in external tonicity increased with the magnitude of the osmotic step change, there was no enhancement of release when the tonicity changes were performed gradually in 0.1-T steps at 1-min intervals. The stimulation of CK release by tonicity changes cannot be ascribed to irreversible loss of functional integrity of the surface or tubular membranes or to CK diffusion through aqueous pores. The possibility that an exocytosislike process is involved is discussed.

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Citations

Jan 1, 1989·Annals of the New York Academy of Sciences·M C Sugden, M J Holness
Jul 17, 1999·The American Journal of Physiology·P GalassettiA D Cherrington
Dec 1, 2015·Diabetes Technology & Therapeutics·Ananda Basu, Rita Basu
Oct 1, 1998·The American Journal of Physiology·V RigalleauH Gin
Sep 12, 2006·The Journal of Pharmacology and Experimental Therapeutics·Dale S EdgertonAlan D Cherrington
Jan 1, 1993·Acta Diabetologica·M A Gomez-ZubeldiaJ E Campillo
Dec 9, 1998·The American Journal of Physiology·P S HsiehA D Cherrington
Aug 5, 1998·The American Journal of Physiology·P GalassettiA D Cherrington
Jul 27, 2001·Diabetes Technology & Therapeutics·T T AokiJ H Ahn
Nov 18, 2006·Annals of Biomedical Engineering·Jaeyeon KimMarco E Cabrera
Feb 23, 2012·Scientific Reports·Sarang N SatoorAnandwardhan A Hardikar
Aug 13, 1999·The American Journal of Physiology·C HanW W Lautt
May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·J Radziuk
May 1, 1991·JPEN. Journal of Parenteral and Enteral Nutrition·A D CherringtonO P McGuinness
Sep 7, 2001·Diabetes/metabolism Research and Reviews·J Radziuk, S Pye

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