Release of diltiazem hydrochloride from hydrophilic matrices of polyethylene oxide and carbopol

Drug Development and Industrial Pharmacy
M VarmaS Dhawan

Abstract

The mucoadhesion, swelling, and drug release behavior of polyethylene oxide (PEO) and carbopol (CP) matrices were studied using a water soluble model drug diltiazem hydrochloride. The mucoadhesive strength of the matrices increased with increase in polymer content. The results showed that PEO was more mucoadhesive than CP. Mucoadhesion of the tablets was dependent upon the swelling. Swelling was ascertained by measuring the axial and radial expansion of matrix tablets following exposure to media of physiological ionic strength. There was a marked increase in the swelling index of matrices containing high polymer content of PEO as compared to CP. Drug release kinetics were found to be closely related to dissolution and swelling properties of the matrices. The release was found to be non-Fickian with n (release exponent) values ranging from 0.45-0.58. At a constant polymer content (15.84% w/w), the main contributing factor for the mucoadhesion, swelling, and release was the amount of PEO.

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Citations

Jul 2, 2009·Drug Development and Industrial Pharmacy·Rishi KapilSanju Dhawan
Aug 20, 2011·Drug Development and Industrial Pharmacy·Valence M K NdesendoLeith C R Meyer
Feb 28, 2008·Drug Development and Industrial Pharmacy·Pablo Emilio Gutiérrez-SánchezLeopoldo Villafuerte-Robles
Sep 5, 2013·Drug Development and Industrial Pharmacy·Lulu MaJianming Chen
Jul 10, 2008·Drug Development and Industrial Pharmacy·Munish Kumar DhimanKrutika K Sawant
Sep 19, 2012·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·A AlmeidaC Vervaet
Jun 5, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Feng ZhangN A Watson
Jun 30, 2016·Journal of Pharmaceutical Sciences·Feng ZhangSamad Momin
Nov 23, 2019·Drug Development and Industrial Pharmacy·Petra DrakslerAnton Meden
Feb 27, 2008·Pharmaceutical Development and Technology·Munish DhimanKrutika K Sawant

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