Release of dopamine from bovine lung by specific antigen and by compound 48-80

British Journal of Pharmacology
P Eyre


1. Dopamine was shown to be released from the isolated lung of calves sensitized with horse serum by compound 48/80 and by specific antigen.2. Dopamine contracts the bovine pulmonary artery and pulmonary vein. Phentolamine, the alpha-adrenoceptor blocking agent, inhibits this activity of dopamine and also strongly reduces the Schultz-Dale response of the pulmonary vessels.3. The results are consistent with the suggestion that dopamine (together with histamine and 5-hydroxytryptamine) may participate in the pulmonary vasoconstriction associated with anaphylaxis in cattle.


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Related Concepts

Histamine Measurement
Pulmonary Arterial Vasoconstriction [PE]
Anaphylaxis (Non Medication)
Pathologic Vasoconstriction
Bos taurus
Adrenergic alpha-Antagonists

Related Feeds


Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.

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