PMID: 7370803May 26, 1980Paper

Release of endogenous amino acid neurotransmitter candidates from rat olfactory cortex slices: possible regulatory mechanisms and the effects of pentobarbitone

Brain Research
G G Collins

Abstract

A study has been made of the regulation of evoked release of the amino acid neurotransmitter candidates (aspartate, GABA and taurine) from rat olfactory cortex slices. The effects of pentobarbitone (10-1000 microM) on release have also been assessed. Release of aspartate, the presumed excitatory transmitter of some of the lateral olfactory tract fibres, is reduced by muscimol (10 microM) and this effect is antagonized by picrotoxin (15 microM): it is concluded that presynaptic GABA receptors may modulate aspartate release. Low concentrations of pentobarbitone also reduce aspartate release, but this effect is picrotoxin-insensitive. Release of GABA, the presumed transmitter of inhibitory interneurones, is reduced by muscimol (10 microM) and this effect is antagonized by picrotoxin (15 microM): it is suggested that GABA release may be regulated by presynaptic autoreceptors. Pentobarbitone significantly increases release of GABA when slices are synaptically activated although the mechanism of this effect is unclear. Release of taurine, not hitherto considered a neurotransmitter in this brain area, is depressed by muscimol (10 microM) and pentobarbitone and increased by picrotoxin (15 microM). Results are discussed in terms of (i) ...Continue Reading

References

Nov 1, 1976·The Journal of Physiology·R M Clark, G G Collins
May 1, 1978·British Journal of Pharmacology·N G Bowery, A Dray
Aug 31, 1978·Nature·P R Mitchell, I L Martin
Aug 1, 1979·European Journal of Pharmacology·S ArbillaS Z Langer
Feb 1, 1978·The Journal of Physiology·H G Pickles, M A Simmonds
Sep 1, 1976·The Journal of Physiology·H G Pickles, M A Simmonds
Mar 11, 1975·Journal of Neurochemistry·J A HarveyM H Aprison
Mar 19, 1976·Brain Research·H F Bradford, C D Richards
Dec 6, 1974·Brain Research·R W CutlerD S Dudzinski
Dec 1, 1972·The Journal of Physiology·C D Richards
Aug 16, 1974·Brain Research·J A HarveyD A Brown
Apr 1, 1972·Hoppe-Seyler's Zeitschrift für physiologische Chemie·G Briel, V Neuhoff
Oct 1, 1963·The Journal of Physiology·J C ECCLESW D WILLIS

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Citations

Jun 1, 1990·Pflügers Archiv : European journal of physiology·R TakedaT Hukuhara
Jan 1, 1982·Progress in Neurobiology·J A Richter, J R Holtman
Jan 1, 1992·Progress in Neurobiology·P Saransaari, S S Oja
Feb 1, 1982·Psychological Medicine·B Meldrum
Jan 1, 1991·Annals of the New York Academy of Sciences·G Pocock, C D Richards
Aug 1, 1982·Journal of Neurochemistry·M Willow, F L Bygrave
Jan 1, 1984·Journal of Neurochemistry·F Fonnum
Oct 1, 1996·Anesthesiology·M B MaclverF A Monroe
Nov 19, 1984·FEBS Letters·A PastuszkoM Erecińska
Feb 17, 1994·Nature·N P Franks, W R Lieb
Jan 1, 1982·British Journal of Pharmacology·T J Kendall, M C Minchin
Jan 1, 1987·British Journal of Pharmacology·G Pocock, C D Richards
Aug 14, 2002·British Journal of Anaesthesia·C D Richards

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