PMID: 3026218Jan 1, 1986Paper

Release of endogenous amino acids, dopamine, and cyclic AMP from the rat brain: methodological aspects and mutual interferences

Annals of the New York Academy of Sciences
J Korf


The release from the rat brain of endogenous dopamine, its metabolites, cyclic AMP, transmitter, and other amino acids was studied with push-pull cannula perfusion or dialysis. The amino acid output from the striatum with either perfusion technique was virtually identical. Relative to the tissue content, the egress of the dopamine metabolites and of the non-transmitter (metabolic) amino acids was higher than that of the transmitter substances. The intracellular second messenger cyclic AMP was also released into the perfusate, and its content was enhanced by local application of various biogenic amines. During and after electroconvulsive shocks the release (and presumably the formation) of alanine was enhanced, which may reflect increased glycolysis and transamination in the brain. Following local application of tricyclic antidepressants, the content of transmitter amino acids in push-pull perfusates of the rat thalamus and striatum was enhanced several fold. Such an increase was not found following systemic injection of high doses of mianserin and desmethylimipramine. In contrast, the effect of amphetamine on dopamine release was seen after both local and systemic applications. Locally applied dopamine produced a specific decre...Continue Reading


Mar 14, 1977·Naunyn-Schmiedeberg's Archives of Pharmacology·G K Aghajanian, B S Bunney
Aug 31, 1978·Nature·P R Mitchell, I L Martin
Aug 1, 1979·European Journal of Pharmacology·S ArbillaS Z Langer
Dec 21, 1979·Brain Research·E P SchoenerD R Schneider
Feb 1, 1979·Journal of Neurochemistry·J A van der HeydenJ Korf
Sep 1, 1972·The Journal of Pharmacy and Pharmacology·W KehrC Atack
Jan 13, 1984·European Journal of Pharmacology·T Zetterström, U Ungerstedt
Feb 12, 1981·Nature·A CheramyJ Glowinski
Sep 1, 1983·Naunyn-Schmiedeberg's Archives of Pharmacology·M G FeenstraA S Horn
Dec 1, 1981·Veterinary Research Communications·J R Brandt, M M Sewell
May 1, 1980·Journal of Neurochemistry·J A van der HeydenJ Korf

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