PMID: 6329437May 28, 1984Paper

Release of endogenous dopamine from electrically stimulated slices of rat striatum

Brain Research
J D Milner, R J Wurtman


An experimental system is described for measuring the release of endogenous dopamine from electrically stimulated slices of rat striatum. Striatal slices were field-stimulated by two high frequency trains (S1 and S2) applied 10, 30 or 60 min apart. The quantities of dopamine released by the two stimuli were compared from slices incubated with and without dopamine's precursor, L-tyrosine. Sustained release of dopamine evoked by the two stimuli was shown to require the inclusion of tyrosine (50 microM) in the superfusate.


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Mar 16, 1976·Naunyn-Schmiedeberg's Archives of Pharmacology·T C WestfallJ Glowinski
Nov 15, 1977·European Journal of Pharmacology·J C Stoof, A H Mulder
Jan 1, 1971·Acta Physiologica Scandinavica. Supplementum·L O Farnebo, B Hamberger
Sep 1, 1972·British Journal of Pharmacology·G Bustos, R H Roth
Jul 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·E MelamedR J Wurtman

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