Release of endothelium-associated proteins into blood by injection of heparin in normal subjects and in patients with Type 1 diabetes

Diabetic Medicine : a Journal of the British Diabetic Association
B MyrupT Olivecrona

Abstract

Disturbances in heparan sulphate proteoglycans in patients with diabetic nephropathy might contribute to the pathogenesis of vascular disease in these patients. To investigate this possible link, we measured the heparin-induced, immediate release of eight proteins with heparan sulphate binding properties in patients with nephropathy. We studied three groups, Type 1 diabetic patients with (n = 10) or without (n = 15) albuminuria and matched controls (n = 12). Blood samples were obtained before and 5 min after the injection of 40 anti-Xa IU low molecular weight heparin/kg body weight. Lipoprotein lipase increased more in diabetic patients without albuminuria than in controls and patients with albuminuria [261 (170-293) vs. 177 (103-438), P < 0.05 and 203 (159-280) mU/ml, P < 0.05]. Total tissue factor pathway inhibitor increased more in the diabetic patients [284 (198-449) and 275 (243-399)] than in the controls [221 (169-289) ng/ml, P < 0.005]. Vitronectin increased significantly only in the diabetic patients with albuminuria. The remaining proteins did not increase significantly (antithrombin, von Willebrand factor, fibronectin) or increased equally in the three investigated groups (extracellular superoxid dismutase and platele...Continue Reading

References

Apr 1, 1989·Diabetologia·T DeckertA Kofoed-Enevoldsen
Nov 15, 1988·The Biochemical Journal·K KarlssonS L Marklund
Feb 15, 1987·The Biochemical Journal·K Karlsson, S L Marklund
Oct 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·B Feldt-RasmussenM Deckert
Jun 4, 1998·Thrombosis Research·K T Preissner, D Seiffert
Mar 21, 2002·European Journal of Clinical Investigation·T RugeG Olivecrona
Mar 30, 2002·Cardiovascular Research·Pascale DufourcqJacques Bonnet
Sep 28, 2002·Current Opinion in Lipidology·Karina Preiss-LandlRudolf Zechner
Oct 4, 2002·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Beata NaumnikMichał Myśliwiec
Jan 10, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·P B LeursB H R Wolffenbuttel

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Citations

Sep 8, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mareille GrittersMenso J Nubé
Mar 28, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Mareille GrittersMenso J Nubé
Feb 25, 2011·Critical Care : the Official Journal of the Critical Care Forum·Heleen M Oudemans-van StraatenRinaldo Bellomo
May 8, 2014·Mediators of Inflammation·Hana KolářováLukáš Kubala
Apr 21, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Amélie I S SobczakAlan J Stewart
Apr 29, 2005·Diabetes/metabolism Research and Reviews

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