Release of Enterococcus mundtii Bacteriocin ST4SA from Self-Setting Brushite Bone Cement

Probiotics and Antimicrobial Proteins
A D van StadenL M T Dicks

Abstract

Maxillofacial and craniofacial surgery is on the increase, which exposes more patients at risk of acquiring microbial infections. The use of antibiotic-loaded calcium phosphate bone cements has been shown to reduce the incidence of infection. A marked increase in antibiotic-resistant pathogens, including multidrug-resistant pathogens, has been reported. This has led to the investigation of various compounds as alternatives to conventional treatments. In this paper, we report on the incorporation and release of a broad-spectrum class II antimicrobial peptide, bacteriocin ST4SA produced by Enterococcus mundtii, into a calcium orthophosphate-based bone cement. Our results suggest class II bacteriocins may be incorporated into self-setting bone cements to produce implants with antimicrobial activity over extended periods of time.

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Citations

Jan 25, 2012·Journal of Applied Microbiology·A D van StadenL M T Dicks
Feb 11, 2019·Biotechnology Letters·Gobinath ChandrakasanNorberto Chavarría-Hernández
Apr 3, 2012·Journal of Applied Biomaterials & Functional Materials·Anton D Van Staden, Leon M T Dicks
Sep 2, 2021·Bioactive Materials·Marco FoscaVuk Uskoković

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