Jul 1, 1977

Release of enzymes from cells: transport and distribution within the extracellular space

Annals of Clinical and Laboratory Science
H Mattenheimer, R Friedel

Abstract

The distribution in the extracellular space of enzymes released from organ cells was investigated using three models: (1) comparison of enzyme activities in blood plasma and lymph of the ductus thoracicus (dog) and plasma and intestinal lymph (rat); (2) i.v. injection of heterologous, homologous and autologous enzymes in order to increase acutely the activities and to measure the rate constants for the distribution and elimination of the enzymes (rat); or (3) plasmapheresis in order to create an enzyme activity gradient from the interstitial space and to determine the rate constants for the reestablishment of the equilibrium between the extra and intravascular compartments (rat). The results suggest that the enzymes are mainly released into the interstitial fluid and transported via the lymph into the intravascular compartment. From there the enzymes diffuse back into the interstitial compartment and are eliminated by a yet unknown mechanism. Transport of enzymes across the capillary membranes in both directions depends on (1) the permeability of the capillary membranes, which varies from region to region and (2) the molecular seizes of the enzymes.

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Mentioned in this Paper

Tissue Membrane
Interstitial Space
Enzymes, antithrombotic
Extracellular Space
Interstitial
Vascular Permeability
Lymph
Enzyme Activity
Enzymes for Treatment of Wounds and Ulcers
Blood Enzyme Activity (Lab Test)

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