Release of gastrin and somatostatin into the gastric lumen of healthy subjects and patients with duodenal ulcer and achlorhydria

Acta Physiologica Scandinavica
O WisénC Johansson

Abstract

Gastrin and somatostatin were measured in alkaline gastric instillates in normal subjects, patients with duodenal ulcer disease in quiescent state and in patients with achlorhydria. Both peptides were released into the lumen. The gastrin-somatostatin ratio (G/S) in healthy subjects was approximately three. Duodenal ulcer patients had significantly lower G/S ratio due to lower gastrin and higher somatostatin levels whereas in patients with achlorhydria, the G/S ratio did not differ from normal subjects.

References

Jan 1, 1977·Acta Physiologica Scandinavica·K Uvnäs-WallenstenR Luft
Oct 1, 1976·Acta Physiologica Scandinavica·K Uvnäs-Wallensten, J F Rehfeld
Jun 26, 1975·The New England Journal of Medicine·J H Walsh, M I Grossman
Feb 25, 1971·The New England Journal of Medicine·W L Trudeau, J E McGuigan

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Citations

Aug 1, 1986·Digestive Diseases and Sciences·H DegertekinA Arimura
Jan 1, 1993·Journal of Pediatric Surgery·J B DasJ G Raffensperger
Aug 1, 1988·Scandinavian Journal of Gastroenterology·M LigumskyD Rachmilewitz

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