PMID: 6405112May 9, 1983Paper

Release of histamine and adrenaline in vivo following intravenous administration of neurotensin

Life Sciences
M OishiS Takaori

Abstract

Plasma histamine levels of rats anesthetized with pentobarbital sodium were significantly increased by intravenous administration of neurotensin (NT, 1 nmole/kg) with the maximum effect at 3 min, and a return to the initial levels in 20 min. Treatment of animals with compound 48/80 or disodium cromoglycate completely inhibited the elevation of histamine level by NT, however, treatment with reserpine or diphenhydramine and adrenalectomy did not affect the elevation. Plasma adrenaline levels increased transiently 1 min after NT injection, and adrenalectomy and treatment with compound 48/80 or diphenhydramine markedly reduced the elevation of adrenaline levels after NT injection. Plasma levels of noradrenaline were unchanged upon NT injection. These results provide direct evidence of the release of endogenous histamine and adrenaline following NT administration, and suggest the contribution of these amines to the NT-induced triphasic blood pressure responses (the first depressor, second pressor and third depressor responses) reported previously.

References

Nov 1, 1979·Naunyn-Schmiedeberg's Archives of Pharmacology·L A Chahl
Mar 1, 1978·The Journal of Physiology·H U BühlerG B Picotti
Mar 15, 1978·Experientia·M Göthert, J M Rieckesmann
Nov 1, 1976·Metabolism: Clinical and Experimental·M BrownW Vale
Dec 1, 1965·British Journal of Pharmacology and Chemotherapy·J Staszewska-Barczak, J R Vane
Jan 1, 1968·Journal of Ultrastructure Research·L G Elfvin
Nov 17, 1980·Life Sciences·R QuirionS St-Pierre
Dec 1, 1981·Japanese Journal of Pharmacology·M OishiY Akazawa
Dec 3, 1981·European Journal of Pharmacology·M Kurose, K Saeki
Mar 1, 1982·Acta Physiologica Scandinavica·P G KrügerK B Helle
Jan 1, 1980·Scandinavian Journal of Gastroenterology·B H SelbekkL E Hanssen
Jun 29, 1953·The Journal of Physiology·W FELDBERG, J TALESNIK

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Citations

May 26, 2015·European Journal of Pharmacology·Oleg E Osadchii
Feb 20, 2021·Behavioural Brain Research·Mélanie VivancosPhilippe Sarret

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