Aug 4, 2001

Release of hydrocortisone from a cream matrix: dependency of release on suspension concentration and measurement of solubility and diffusivity

Pharmaceutical Development and Technology
R PillaiG L Flynn


The principal object of the present research was to investigate the sensitivity of drug release from a semisolid system to the manner of its preparation and to the concentration of drug placed within it. Established theory indicated that release should be concentration dependent, with the specific dependency determined by whether the drug in the system is fully in solution or is present substantially as suspended matter. To purposefully explore these relatively untested performance expectations, the total amount of drug in the formula was varied from a low concentration of 0.25% to a high concentration of 3%. Conditions were established such that drug release conformed to release from a semi-infinite medium into a receptor sink. At every concentration, release profiles were well reproduced in replicate samples and, where multiple lots of a kind were employed, from lot to identical lot. In all cases square root of time release kinetics were observed. Moreover and without exception, the square root of time release rate from run to run was directly proportional to the square root of the total concentration of hydrocortisone placed in the formulations. The amount released per square root of time per square root of total concentrati...Continue Reading

  • References4
  • Citations5


  • References4
  • Citations5


Mentioned in this Paper

Drug Formulation Process
Controlled-Release Preparations
Anti-Inflammatory Agents
Administration, Topical
Transdermal Route of Drug Administration
Cortisol Measurement
Therapeutic Equivalency
Hydrocortisone, (9 beta,10 alpha,11 alpha)-Isomer

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