Release of hypoacetylated and trimethylated histone H4 is an epigenetic marker of early apoptosis.

The Journal of Biological Chemistry
Manuel Boix-ChornetEsteban Ballestar

Abstract

Nuclear events such as chromatin condensation, DNA cleavage at internucleosomal sites, and histone release from chromatin are recognized as hallmarks of apoptosis. However, there is no complete understanding of the molecular events underlying these changes. It is likely that epigenetic changes such as DNA methylation and histone modifications that are involved in chromatin dynamics and structure are also involved in the nuclear events described. In this report we have shown that apoptosis is associated with global DNA hypomethylation and histone deacetylation events in leukemia cells. Most importantly, we have observed a particular epigenetic signature for early apoptosis defined by a release of hypoacetylated and trimethylated histone H4 and internucleosomal fragmented DNA that is hypermethylated and originates from perinuclear heterochromatin. These findings provide one of the first links between apoptotic nuclear events and epigenetic markers.

References

Apr 8, 1988·Cell·H Cedar
Jan 1, 1994·Developmental Genetics·A P Wolffe
Aug 2, 1996·The Journal of Biological Chemistry·E BallestarL Franco
Dec 1, 1996·The Journal of Cell Biology·L RaoE White
Apr 18, 1997·The Journal of Biological Chemistry·C AlleraC Balbi
Jul 22, 1998·Proceedings of the National Academy of Sciences of the United States of America·X LiuX Wang
Sep 12, 1998·The Journal of Biological Chemistry·M J HendzelJ P Th'ng
Feb 13, 1999·Nature Genetics·P A Jones, P W Laird
May 14, 1999·Current Opinion in Genetics & Development·M Cockell, S M Gasser
Jul 15, 1999·Nature Structural Biology·F Winston, C D Allis
Jan 19, 2000·Nature·B D Strahl, C D Allis
Mar 29, 2000·The Journal of Biological Chemistry·E P RogakouW M Bonner
May 12, 2000·Journal of Structural Biology·J D RobertsonB Zhivotovsky
Jun 30, 2000·The Journal of Biological Chemistry·M KratzmeierD Doenecke
Jan 4, 2001·The Journal of Biological Chemistry·C A JohnsonB M Turner
Jul 5, 2001·Cellular and Molecular Life Sciences : CMLS·J R Dobosy, E U Selker
Jul 14, 2001·Nature·M O Hengartner
Aug 14, 2001·Journal of Cellular Biochemistry·A M MartelliR Bortul
Jan 29, 2002·The Journal of Biological Chemistry·Dongcheng WuDamu Tang
Jul 12, 2002·Nature·Paola ScaffidiMarco E Bianchi
Aug 3, 2002·The Journal of Biological Chemistry·Bettina SargHerbert H Lindner
Aug 3, 2002·Oncogene·Melanie Ehrlich
Sep 20, 2002·BioTechniques·Mario F Fraga, Manel Esteller
Mar 22, 2003·Science·Kathrin PlathYi Zhang
Jul 8, 2003·International Journal of Cancer. Journal International Du Cancer·Jacek WojciechowskiJózefa Węsierska-Gądek
Aug 26, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Alfons Lawen
Sep 6, 2003·Methods : a Companion to Methods in Enzymology·Andreas Mackensen, Peter Brossart
Dec 24, 2003·Molecular Cell·Antoine H F M PetersThomas Jenuwein
Jan 28, 2004·Cell·Sepideh Khorasanizadeh
Feb 26, 2004·Methods in Enzymology·Tiziana BonaldiAxel Imhof
May 7, 2004·Journal of Cell Science·Niki KourmouliPrim B Singh
May 18, 2004·Genes & Development·Gunnar SchottaThomas Jenuwein
Jun 29, 2004·The Journal of Biological Chemistry·Jesus EspadaManel Esteller
Jul 16, 2004·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Susan GilchristWendy A Bickmore

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Citations

Oct 30, 2007·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Angela O ChoiDusica Maysinger
Feb 16, 2008·Analytical and Bioanalytical Chemistry·Stefano OlmoVanni Cavrini
May 15, 2010·Cell Death and Differentiation·J FüllgrabeB Joseph
Sep 22, 2011·BMC Cell Biology·Kristin M SladeEmily A Wiley
Nov 6, 2009·Drug News & Perspectives·M B Lustberg, B Ramaswamy
Dec 17, 2011·International Journal of Molecular Sciences·Andrew W FarrellJames Guy Lyons
Oct 17, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Mathieu VinkenTamara Vanhaecke
Aug 29, 2006·Biochemical Pharmacology·Wim Vanden BergheGuy Haegeman
Jun 25, 2015·Carcinogenesis·Sabine A S LangieAndrew R Collins
Oct 2, 2012·Biochimie·Soňa LegartováEva Bártová
May 2, 2014·Frontiers in Immunology·Elmar Pieterse, Johan van der Vlag
Oct 25, 2016·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Pragnesh Mistry, Mariana J Kaplan
Jun 6, 2009·Journal of Dental Research·S P Barros, S Offenbacher
Nov 19, 2008·The Journal of Biological Chemistry·Noemí Blanco-GarcíaMarian A Martínez-Balbás
Dec 2, 2020·International Journal of Molecular Sciences·Pradeep Kumar RajanJuan Sanabria
Nov 26, 2010·Archives of Biochemistry and Biophysics·Yoichiro YamadaSei-ichi Tanuma
Jan 2, 2008·Biochimica Et Biophysica Acta·Samir Kumar Patra

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