Release of immunoreactive substance P in the trigeminal brain stem nuclear complex evoked by chemical stimulation of the nasal mucosa and the dura mater encephali--a study with antibody microprobes

Neuroscience
H G SchaibleK Messlinger

Abstract

In order to study a possible involvement of substance P in the processing of chemonociceptive input from the nasal mucosa and the dura mater encephali in the spinal trigeminal, the release of immunoreactive substance P was measured in the trigeminal brain stem nuclear complex in anaesthetized rats. Microprobes coated with antibody to substance P were inserted into the lateral area of the brain stem up to 1 mm posterior to the obex corresponding to the trigeminal subnucleus caudalis. When the nasal mucosa was stimulated by topical administration of mustard oil (1% and 5%) into the nostrils, immunoreactive substance P was mainly detected in the dorsal region of the trigeminal brain stem nuclear complex with a maximum in the superficial gray matter. When the dura mater encephali was stimulated by topical administration of Tyrode's solution (pH 6.2), immunoreactive substance P was mainly released in the ventral region of the trigeminal brain stem nuclear complex; with pH 5.5 the release was more diffuse extending from the ventral to the dorsal part of the spinal trigeminal nucleus. Release was maximal rather after than during the administration of the stimuli, and it considerably outlasted the stimulation periods. These data sugges...Continue Reading

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Feb 11, 2014·The Journal of Headache and Pain·Charlotte KageneckMichael Jm Fischer
Jun 19, 2001·Critical Reviews in Toxicology·V J FeronR A Woutersen
Aug 30, 2003·Current Pain and Headache Reports·Elcio J PiovesanMichael L Oshinsky
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Mar 14, 2018·The Journal of Headache and Pain·Karl Messlinger
Apr 12, 2019·Pharmaceuticals·Silvia Benemei, Greg Dussor

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