PMID: 2510291Oct 1, 1989Paper

Release of interleukin 2 and gamma interferon by peripheral mononuclear cells in human Schistosoma mansoni infection normalizes after chemotherapy

Scandinavian Journal of Immunology
K ZwingenbergerH Feldmeier

Abstract

Interleukin 2 (IL-2) and gamma interferon (IFN-gamma) were determined in supernatants of mitogen- and antigen-driven cell cultures from patients with hepatosplenic or intestinal schistosomiasis. Skin reactivity was tested using a panel of eight recall antigens. Results were compared with those of uninfected local controls. In both schistosomiasis groups, IL-2 activity was reduced before treatment. In less than one third of the patients, schistosomal antigens elicited detectable IL-2 activity. IFN-gamma production was reduced more severely in hepatosplenic cases, in particular after stimulation by anti-CD3 monoclonal antibodies. After anti-schistosomal therapy with praziquantel, mitogen-induced IL-2 and IFN-gamma activities became normal within 3 months in intestinal schistosomiasis, and within 6 months in the hepatosplenic patient group. Results of in vivo delayed-type hypersensitivity tests paralleled those of in vitro lymphokine production. In conclusion, evidence is presented for severe, antigen-unspecific suppression of lymphokine production and skin reactivity against recall antigens. Anti-parasitic chemotherapy is shown to reverse the impairment of cell-mediated immune responses at the cytokine level.

References

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Citations

Jan 1, 1991·Journal of Tongji Medical University = Tong Ji Yi Ke Da Xue Xue Bao·Z J LiX H Wang
Feb 27, 2007·Parasitology Research·Roba M TalaatMaged M Al-Sherbiny
Jan 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·L M Bahia-OliveiraR Correa-Oliveira
Jul 1, 1994·Transactions of the Royal Society of Tropical Medicine and Hygiene·I R VianaR Correa-Oliveira
Jan 1, 1994·International Journal of Antimicrobial Agents·V Kumar, B Gryseels
Aug 1, 1993·Current Opinion in Immunology·R L Modlin, T B Nutman
May 29, 2002·Tropical Medicine & International Health : TM & IH·Gundel Harms, Hermann Feldmeier
Apr 1, 1992·Revista Da Sociedade Brasileira De Medicina Tropical·G Gazzinelli, D G Colley
Jun 1, 1990·Scandinavian Journal of Immunology·K ZwingenbergerA R Correia Dacal
Jun 1, 1996·European Journal of Immunology·M I AraújoE M Carvalho
Mar 6, 1998·British Journal of Haematology·G S GerhardM J Chorney
Aug 1, 1992·Immunological Investigations·A J DesseinA Bourgois
Jan 7, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mark BoothDavid W Dunne

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