Release of intestinal diamine oxidase by histamine in rats

Canadian Journal of Physiology and Pharmacology
Armin Wollin, H Navert

Abstract

Diamine oxidase activity was measured in the intestinal mucosa, lymph, and in the serum of rats, to determine whether histamine, a substrate of diamine oxidase, liberates this enzyme from its mucosal storage site(s). Histamine induced a sharp rise in intestinal lymph flow, lymph protein, and lymph diamine oxidase, lasting less than 1 h after the histamine injection. The rise in lymph diamine oxidase activity was dose dependent over a narrow concentration range (0.05-0.2 mmol/kg, i.v. and 0.15-0.6 mmol/kg i.d.). It did not correlate with the dose dependent increase in lymph flow or lymph protein. A single maximal intraduodenal dose of histamine caused a 41.6-fold increase in the lymph diamine oxidase activity and a 2.4-fold increase in the serum enzyme level temporarily. A second injection of histamine, 2 h after the first, resulted in a comparatively smaller increase in the lymph enzyme. The extent of the reduction was dependent on the magnitude of the first injection. The results suggest that histamine causes a limited liberation of diamine oxidase from the intestinal mucosa. The function of this enzyme release may be a protective response by the mucosa to reduce toxic levels of free histamine, either liberated by the mucosal ...Continue Reading

Citations

Feb 16, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yong JiPatrick Tso
May 6, 2006·The Journal of Allergy and Clinical Immunology·Laura MaintzNatalija Novak
Jan 1, 1986·Critical Reviews in Toxicology·S L Taylor
Oct 2, 1998·The American Journal of Physiology·A WollinP Tso

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