Release of iron from ferritin by 1,2,4-benzenetriol

Chemico-biological Interactions
S AhmadG S Rao

Abstract

Release of iron from ferritin in the presence of polyhydroxy metabolites of benzene i.e., hydroquinone (HQ) or 1,2,4-benzenetriol (BT) was studied in acetate buffer, pH 5.6. The release of iron from ferritin was quantitated by monitoring the formation of iron-ferrozine complex. The presence of hydroquinone (330 microM) did not result in the release of iron from ferritin, whereas the same concentration of BT resulted in the release of significant amounts of iron (3.2 microM/min) from ferritin. BT concentration-dependent increase in iron release from ferritin was observed although the increase was not linear with the concentration of BT. Under a N2 atmosphere the presence of BT resulted in the release of iron (2.1 microM/min) from ferritin. The presence of oxyradical scavengers i.e., albumin, catalase or superoxide dismutase significantly inhibited iron release from ferritin by BT. The iron released from ferritin by BT enhanced lipid peroxidation in rat brain homogenate and released aldehydic products from bleomycin-dependent degradation of DNA. Addition of BT to bone marrow lysate resulted in an increase of iron release as a function of time. These studies indicate that BT is a potent reductant of ferric iron of ferritin and als...Continue Reading

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Citations

Nov 9, 2000·Archives of Biochemistry and Biophysics·S AhmadW R Cullen
Jan 1, 1996·Free Radical Biology & Medicine·L ZhangA J Davison
May 16, 2002·Journal of Inorganic Biochemistry·Michael J Hynes, Máirtín O Coinceanainn
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Feb 11, 2005·Dalton Transactions : an International Journal of Inorganic Chemistry·Purificación SánchezJosé M Domínguez-Vera
Nov 13, 2010·Metallomics : Integrated Biometal Science·Casey S Jackson, Jeremy J Kodanko
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Nov 10, 2010·Chemical Communications : Chem Comm·Fadi Bou-AbdallahArtem Melman
Nov 20, 2009·Journal of Agricultural and Food Chemistry·Jianjun DengGuanghua Zhao

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