PMID: 6162898Jan 1, 1980Paper

Release of mediators from free bronchoalveolar cells: effect of ionophore A23187 and antigen challenge

Journal of Immunopharmacology
P Sirois

Abstract

The ionophore A23187 stimulated the release of prostaglandins and SRS-A (now identified as leukotriene D4) from guinea-pig bronchoalveolar macrophages. Upon specific antigen challenge of the cells obtained from ovalbumin-sensitized animals or of normal cells preincubated with the serum of sensitized animals, prostaglandins, SRS-A or histamine were undetectable. Furthermore, treatment of "sensitized" cells with the ionophore resulted in a reduced liberation of prostaglandins in comparison to control cells. It is suggested that sensitization produce in bronchoalveolar macrophages some functional alterations of arachidonic acid oxygenation products.

Citations

Feb 1, 1991·The Journal of Pharmacy and Pharmacology·A YamamotoS Tanaka
Feb 1, 1983·The Journal of Clinical Investigation·M JosephJ Benveniste
Dec 22, 2000·The American Journal of Clinical Nutrition·D D SchrammC L Keen

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