PMID: 428820Feb 1, 1979Paper

Release of motilin by oral and intravenous nutrients in man

Gut
N D ChristofidesM A Ghatei

Abstract

Motilin is a hormonal peptide found in the duodenum and jejunum which potently influences gastrointestinal tract motility. Its role in human physiology is not yet established. After a standard hospital lunch the plasma concentration of motilin showed a small, transient, but significant rise in 28 healthy subjects. Individual food components either stimulated (oral fat) or suppressed release (oral glucose). Plasma motilin levels were, in addition, altered to an equal extent by intravenous nutrients, with glucose and amino acids suppressing release, and intravenous fat causing a significant rise in plasma concentration. These results demonstrate a consistent response to food stimuli, whether oral or intravenous. The release mechanism appears to be complicated and after a balanced meal, containing food components which both stimulate and suppress release, there is only a small net change.

References

Apr 24, 1976·Lancet·P MitzneggL Demling
Mar 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A M KappelgaardJ Giese

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Citations

Oct 1, 1992·Digestive Diseases and Sciences·M BoivinP Poitras
Feb 1, 1993·Digestive Diseases and Sciences·E E SofferT E Adrian
Jul 1, 1981·Digestive Diseases and Sciences·D L Wingate
Jan 1, 1994·Digestive Diseases and Sciences·E E SofferT E Adrian
Jul 1, 1993·Diseases of the Colon and Rectum·W E Longo, A M Vernava
Jun 20, 2007·International Journal of Colorectal Disease·Amosy E M'KomaAlan J Herline
Aug 4, 1982·Clinica Chimica Acta; International Journal of Clinical Chemistry·N D ChristofidesS R Bloom
Sep 9, 1986·European Journal of Pharmacology·L D Hirning, T F Burks
Jan 1, 1981·Regulatory Peptides·K MoriH Imura
Sep 1, 1985·Peptides·R Schick, V Schusdziarra
Dec 25, 2002·Trends in Pharmacological Sciences·Sidath Katugampola, Anthony Davenport
Jan 1, 1997·Peptides·Z Itoh
Jan 1, 1991·The British Journal of Nutrition·F A SagherK E Carr
Nov 20, 1982·British Medical Journal·N D ChristofidesM D Gillmer
Jan 1, 1978·Journal of Clinical Pathology. Supplement (Association of Clinical Pathologists)·N D Christofides
Jul 1, 2009·Journal of Clinical Gastroenterology·Noriyuki HataHiroyuki Okano
Aug 1, 1985·Scandinavian Journal of Gastroenterology·T SvenbergR B Welbourn
Jan 1, 1995·Scandinavian Journal of Gastroenterology. Supplement·P PortincasaG P van Berge-Henegouwen
Mar 1, 1996·American Journal of Surgery·G TzovarasJ S Vassilakis
Aug 1, 1982·European Journal of Clinical Investigation·R G LongS R Bloom
Jun 1, 1980·European Journal of Clinical Investigation·T E AdrianS R Bloom
Aug 20, 2005·Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]·Lisa StrömmerUrban Arnelo
Jul 1, 1979·Clinics in Endocrinology and Metabolism·S R Bloom, J M Polak
Apr 12, 1990·The New England Journal of Medicine·J JanssensR Bouillon
Jul 1, 1990·Diabetic Medicine : a Journal of the British Diabetic Association·F RequejoS R Bloom
Sep 1, 1987·Scandinavian Journal of Gastroenterology·M HansonE Trell
Mar 16, 2011·Digestion·Eiji NakamuraKunio Torii
Apr 1, 1995·Journal of Internal Medicine·P M HellströmT Svenberg
Mar 1, 1995·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·I NilssonP M Hellström
Jan 1, 1983·Scandinavian Journal of Gastroenterology·O LawaetzD N Ralphs

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