PMID: 848803Apr 1, 1977Paper

Release of neutrophil chemotactic activity during immediate hypersensitivity reactions in humans

Annals of Internal Medicine
P C AtkinsB Zweiman

Abstract

Heat-stable, serum-derived chemotactic activity for neutrophils is shown in a human model of immunoglobulin E-mediated asthma. Twenty-six ragweed-sensitive subjects underwent bronchial provocation challenge using ragweed and Mecholyl. Increased neutrophil chemotactic activity was found in serum tested from 5 to 30 min after a positive ragweed-inhalation challenge, but not after negative ragweed challenge. The appearance of neutrophil chemotactic activity did not reflect the effects of bronchospasm alone, because it was not found after bronchospastic responses to Mecholyl in the same subjects. There were no accompanying changes of serum complement activity, nor evidence of inhibition of the chemotactic activity by proir exposure to antisera to the third and fifth components of complement. Ultrafiltration of serum showed chemotactic activity contained in fractions of at least 50 000 daltons. This appears to be the first demonstration of neutrophil chemotactic activity liberated during experimentally induced immunoglobulin E-mediated asthma in humans.

Citations

Sep 1, 1983·Inflammation·S Wescott, M Kaliner
Nov 1, 1980·The Journal of Allergy and Clinical Immunology·N A Soter, S I Wasserman
Dec 1, 1988·The Journal of Allergy and Clinical Immunology·U PipkornL Enerback
Jan 1, 1988·International Journal of Immunopharmacology·A TsicopoulosA Capron
Oct 24, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Dennis K Ledford
Apr 9, 1998·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·H S Park, K S Jung
Mar 13, 1980·The New England Journal of Medicine·N A SoterE R McFadden
Mar 4, 1982·The New England Journal of Medicine·L NagyA B Kay
Jun 23, 1983·The New England Journal of Medicine·T H LeeA B Kay
May 24, 1984·The New England Journal of Medicine·A A GerblichM R Schuyler
Apr 1, 1990·Acta Paediatrica Japonica; Overseas Edition·T NagakuraY Iikura
Dec 1, 1987·The American Review of Respiratory Disease·D R BuchananA B Kay
Mar 1, 1988·The American Review of Respiratory Disease·N MeslierH A Boushey
Apr 1, 1988·The American Review of Respiratory Disease·D K ZawadskiE R McFadden
Sep 1, 1989·The American Review of Respiratory Disease·U PipkornL Enerbäck
Aug 1, 1990·The American Review of Respiratory Disease·R DjukanovićS T Holgate
Mar 1, 1980·The Journal of Clinical Investigation·E C DealE R McFadden
Apr 1, 1980·Environmental Health Perspectives·S I Wasserman
Apr 1, 1984·Environmental Health Perspectives·S I Wasserman
Apr 1, 1986·Environmental Health Perspectives·J A CooperJ B Gee
Jan 1, 1984·Experimental Lung Research·J R Snapper, K L Brigham
Mar 1, 1985·Pathology, Research and Practice·M R ParwareschK Lennert
Jan 29, 2016·TheScientificWorldJournal·Hélène SénéchalJean-Pierre Sutra
Aug 1, 1983·Journal of the American Academy of Dermatology·B A GilchrestJ A Parrish
Nov 1, 1987·The Journal of Allergy and Clinical Immunology·L P BouletJ Hébert
Dec 1, 1980·The Journal of Allergy and Clinical Immunology·P C AtkinsB Zweiman
Jun 1, 1980·The Journal of Allergy and Clinical Immunology·P PhanuphakH N Claman
Sep 1, 1980·The Journal of Allergy and Clinical Immunology·G L MartinB Zweiman
Jan 1, 1983·Clinical Allergy·P W IndC T Dollery
Jul 1, 1980·Clinical Allergy·T S OrrM A Stern
Nov 1, 1982·The Journal of Allergy and Clinical Immunology·E SchenkelB Zweiman
May 1, 1991·The Journal of Allergy and Clinical Immunology·A B Kay
Nov 1, 1978·The Journal of Allergy and Clinical Immunology·J L RubinH R Hill
Oct 1, 1979·The Journal of Allergy and Clinical Immunology·S I Wasserman, D M Center

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Allergies & Environmental Factors

Environmental factors are strongly associated with the prevalence of allergies and are an increasing health concern worldwide. Discover the latest research on Allergies and Environmental Factors here.

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.