PMID: 6539805Jul 1, 1984Paper

Release of oxytocin and vasopressin by magnocellular nuclei in vitro: specific facilitatory effect of oxytocin on its own release

The Journal of Endocrinology
F MoosP Richard

Abstract

The release of endogenous oxytocin and vasopressin by rat paraventricular and supraoptic nuclei in vitro during a 10-min period, 30 min after beginning the incubation, was measured radioimmunologically. Mean basal hormone release per 10 min and per pair of nuclei was: 128.4 +/- 12.4 (S.E.M.) pg vasopressin (n = 15) and 39.0 +/- 3.0 pg oxytocin (n = 66) for supraoptic nuclei from male rats; 273.9 +/- 42.6 pg vasopressin (n = 11) and 34.2 +/- 3.5 pg oxytocin (n = 15) for supraoptic nuclei from lactating rats; 70.0 +/- 8.6 pg vasopressin (n = 52) and 21.8 +/- 1.3 pg oxytocin (n = 68) for paraventricular nuclei from male rats; 59.1 +/- 8.6 pg vasopressin (n = 10) and 27.0 +/- 4.6 pg oxytocin (n = 16) for paraventricular nuclei from lactating rats. In male and lactating rats, both nuclei contained and released more vasopressin than oxytocin. For oxytocin alone, the paraventricular nucleus of male rats contained and released significantly less hormone than the supraoptic nucleus. This difference was not apparent in lactating rats. For vasopressin alone, the paraventricular nucleus contained and released significantly less hormone than the supraoptic nucleus in both male and lactating rats. When the hormone released was calculated as ...Continue Reading

Citations

Sep 26, 2013·Reviews in Endocrine & Metabolic Disorders·James E Blevins, Jacqueline M Ho
Oct 1, 1990·Pharmacology, Biochemistry, and Behavior·A ArgiolasG L Gessa
May 1, 1992·Pharmacology, Biochemistry, and Behavior·M R MelisA Argiolas
May 1, 1994·Pharmacology, Biochemistry, and Behavior·M R MelisA Argiolas
Jan 1, 1987·Psychoneuroendocrinology·M AnsseauG Franck
Jun 1, 1988·Brain Research Bulletin·M J Freund-MercierJ D Vincent
Jul 16, 2013·Progress in Neurobiology·Antonio Argiolas, Maria Rosaria Melis
Apr 29, 1998·European Journal of Pharmacology·A Argiolas, M R Melis
Mar 1, 2003·Frontiers in Neuroendocrinology·John A RussellAlison J Douglas
May 15, 2003·Trends in Neurosciences·Mike Ludwig, Quentin J Pittman
Sep 1, 1997·Neurochemistry International·I Neumann

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