PMID: 9436574Jan 22, 1998Paper

Release of proinflammatory cytokines during pediatric cardiopulmonary bypass: heparin-bonded versus nonbonded oxygenators

The Annals of Thoracic Surgery
S AshrafK G Watterson

Abstract

Heparin bonding of the cardiopulmonary bypass (CPB) circuit may be associated with a reduced inflammatory response and improved clinical outcome. The relative contribution of a heparin-bonded oxygenator (ie, >80% of circuit surface area) to these effects was assessed in a group of pediatric patients. Twenty-one pediatric patients undergoing CPB operations were assigned randomly to receive either a heparin-bonded oxygenator (group H, n = 11) or a nonbonded oxygenator (group C, n = 10) in otherwise nonbonded circuits. The two groups were similar in pathology, age, weight, CPB time, and cross-clamp time. Plasma levels of the cytokines tumor necrosis factor-alpha, interleukin-6, and interleukin-8, as well as terminal complement complex, neutrophils, and elastase, were analyzed before, during, and after CPB. Significant levels of tumor necrosis factor-alpha were not detected in either group. Plasma levels of all other markers increased during and after CPB compared with baseline. Plasma levels of interleukin-6 peaked in both groups 2 hours after the administration of protamine but remained significantly higher in group C 24 hours after operation. Plasma concentrations of interleukin-8 peaked at similar levels in both groups 30 minut...Continue Reading

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Citations

Mar 10, 2001·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·Y MisawaK Fuse
Feb 5, 2000·The Japanese Journal of Thoracic and Cardiovascular Surgery : Official Publication of the Japanese Association for Thoracic Surgery = Nihon Kyōbu Geka Gakkai Zasshi·T OzawaY Takanashi
Aug 6, 1998·The Annals of Thoracic Surgery·H H SchreursA J Bogers
Dec 10, 1999·The Annals of Thoracic Surgery·S B HortonT R Karl
Mar 29, 2000·The Annals of Thoracic Surgery·T OzawaY Takanashi
Oct 29, 2000·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·F De SomerG Van Nooten
Dec 4, 2002·Artificial Organs·Masanori FujitaTadaaki Maehara
Dec 31, 2003·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Jodie Y DuffyJeffrey M Pearl
Jun 25, 2008·The Annals of Thoracic Surgery·Matthias SiepeChristian Schlensak
Feb 26, 2008·American Heart Journal·Christopher RatnasamyPaolo Rusconi
May 30, 2006·The Annals of Thoracic Surgery·Tain-Yen Hsia, Peter J Gruber
Aug 2, 2000·The Annals of Thoracic Surgery·E A GrossiS B Colvin
Aug 2, 2000·The Annals of Thoracic Surgery·E A GrossiA LaPietra
Jul 18, 2002·The Annals of Thoracic Surgery·John ButlerGeoffrey A Berg
Mar 21, 2003·The Annals of Thoracic Surgery·Eva JensenJohn Ouchterlony
Jun 13, 2015·Advances in Pharmacological Sciences·Sarah MousaviMaryam Motamedi
Oct 17, 2018·World Journal for Pediatric & Congenital Heart Surgery·Matthew F BarhightKatja M Gist
Dec 3, 2005·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Yukihiko NoséTadashi Motomura
Aug 24, 1999·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·S AshrafK Watterson
Dec 8, 2000·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Y MisawaK Fuse
Aug 24, 1999·Perfusion·M J Elliott

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