Release of prostaglandin from the rabbit isolated heart following vagal nerve stimulation or acetylcholine infusion

British Journal of Pharmacology
M Junstad, A Wennmalm


1 Rabbit hearts were perfused by the Langendorff technique. The lipid fraction in the perfusate from the heart was isolated and analysed for prostaglandins by thin layer chromatography and quantitative assay on the rat isolated stomach strip.2 Infusion of acetylcholine at a rate of 8 mug/min significantly increased the outflow of prostaglandins from the heart, from 1.8 to 6.2 ng/minute.3 Addition of atropine (1 mug/ml) to the perfusing medium completely abolished not only the mechanical response but also the increase in outflow of prostaglandins caused by infusion of acetylcholine.4 Bilateral stimulation of the parasympathetic nerves to the heart at 5 Hz also significantly increased the outflow of prostaglandins from the organ from 5.2 to 8.3 ng/minute.5 Both prostaglandin E(1) and E(2) were isolated from the lipid fraction of the perfusate.6 The role of prostaglandins in relation to autonomic neurotransmission in the heart is discussed.


Jan 1, 1971·Physiological Reviews·L B Geffen, B G Livett
May 1, 1970·Acta Physiologica Scandinavica·P HedqvistA Wennmalm
Apr 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·A Wennmalm, P Hedqvist
Jan 1, 1973·British Journal of Pharmacology·S H FerreiraJ R Vane
Apr 1, 1973·Prostaglandins·M S MinkesP Needleman
Dec 1, 1972·Acta Physiologica Scandinavica·L Stjärne
May 1, 1974·Acta Physiologica Scandinavica·A WennmalmS Junstad
Jun 22, 1968·Nature·N GilmoreJ H Wyllie
Oct 1, 1967·The American Journal of Physiology·F CoceaniL S Wolfe
May 27, 1955·The Journal of Physiology·J DEL CASTILLO, B KATZ
Apr 1, 1952·The Journal of Physiology·J DEL CASTILLO, L STARK


Jul 1, 1993·Naunyn-Schmiedeberg's Archives of Pharmacology·K RackéI Wessler
Mar 15, 1981·The Journal of Membrane Biology·A W Cuthbert, S A Wilson
Jul 1, 1981·American Heart Journal·D N MohrJ E Markis
Jun 1, 1997·Biochemical Pharmacology·B V Sastry
Sep 1, 1975·British Journal of Pharmacology·W Feniuk, B J Large
Jul 1, 1976·British Journal of Pharmacology·J GripenbergE M Tolppanen
Dec 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·R Serio, E E Daniel
Feb 1, 1978·Pharmacological Research Communications·L CavalliniN Siliprandi
Nov 1, 1978·The Journal of Pharmacy and Pharmacology·F RengoR Violini
Jan 1, 1979·Scandinavian Journal of Haematology. Supplementum·A Kirstein
Jan 1, 1980·Acta Medica Scandinavica. Supplementum·H VapaataloK Laustiola

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