Release of prostaglandin I2-like activity from the rat aorta: effect of captopril, furosemide, and sodium

Prostaglandins
J M Sullivan, D R Patrick

Abstract

The effect of captopril, furosemide, indomethacin and intake of sodium on the production of PGI2-like material was studied in the rat aorta. Release of PGI2-like material from these vessels was estimated by its ability to inhibit ADP-induced platelet aggregation. Pretreatment with indomethacin (15 mg/kg/day) reduced the capacity of the aorta to release PGI2-like material. Pretreatment with captopril (10 mg/kg/day) had no effect. Intravenous furosemide (60 microgram/ml plasma volume) increased the capacity of the aorta to inhibit by 28% (p less than 0.25). The inhibitory capacity of aorta removed from rats on a low sodium diet did not differ from those on a high sodium diet. We conclude that the action of furosemide in reducing vascular tone may be related to stimulation of PGI2 synthesis in blood vessels whereas the effect of captopril and sodium in reducing vascular tone may involve a mechanism unrelated to PGI2 synthesis or may involve the synthesis of a prostaglandin other than PGI2.

References

Jul 29, 1975·European Journal of Clinical Investigation·F DrayJ Maclouf
Oct 1, 1975·Proceedings of the Society for Experimental Biology and Medicine·H E WilliamsonD E Van Orden
Oct 1, 1971·Biochimica Et Biophysica Acta·D W Cushman, H S Cheung
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Citations

Jun 1, 1986·Clinical and Experimental Pharmacology & Physiology·S J ArmsworthA J Smith
Oct 8, 2009·Pediatric Research·Katsuaki ToyoshimaToshio Nakanishi
Jan 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·V LaheraJ A Tresguerres
Aug 1, 1986·Australian and New Zealand Journal of Medicine·A DavisE J Begg
Jun 1, 1984·British Journal of Pharmacology·A E BardenR Vandongen
Oct 1, 1984·British Journal of Pharmacology·J F Gerkens, A J Smith

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