Release of sensory neuropeptides in the spinal cord: studies with calcitonin gene-related peptide and galanin.

Neuroscience
C R Morton, W D Hutchison

Abstract

In anaesthetized cats, antibody microprobes were used to investigate the release of immunoreactive calcitonin gene-related peptide and galanin in the lower lumbar spinal cord. In the absence of applied stimulation, a basal release of both peptides was detected at the level of the substantia gelatinosa. This release of calcitonin gene-related peptide was not altered by innocuous thermal cutaneous stimulation nor by electrical stimulation of low-threshold myelinated primary afferent fibres, but was increased by noxious thermal or noxious mechanical cutaneous stimuli and by electrical stimulation of unmyelinated primary afferents. A simultaneous release of both calcitonin gene-related peptide and substance P was detected in the substantia gelatinosa region by the use of pairs of microprobes. In contrast, none of the peripheral stimulation procedures increased intraspinal galanin release. The results suggest that the spinal transmission of nociceptive information may involve the simultaneous release and action of several neuropeptides within the superficial layers of the dorsal horn.

Associated Clinical Trials

References

May 23, 1985·Neuroscience Letters·J D LeahP J Snow
Aug 1, 1985·Brain Research Bulletin·G Skofitsch, D M Jacobowitz
Jun 22, 1986·The Journal of Comparative Neurology·T MelanderA Rökaeus
Oct 8, 1986·Neuroscience Letters·M YanagisawaN Yanaihara
Apr 1, 1988·Journal of Neuroscience Methods·I A HendryA W Duggan
Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S De Biasi, A Rustioni
Apr 1, 1988·Acta Physiologica Scandinavica·C PostT Hökfelt
Dec 1, 1988·Neuroscience·A A CameronP J Snow
May 29, 1989·Brain Research·C R MortonA W Duggan
Mar 15, 1988·The Journal of Comparative Neurology·P A HarmannS M Carlton
Apr 1, 1988·Journal of Neuroscience Methods·A W DugganW D Hutchison

❮ Previous
Next ❯

Citations

Sep 1, 1999·Microscopy Research and Technique·S Reuss
Nov 1, 1994·Journal of Neuroscience Methods·A H WaterfallG W Bennett
Aug 1, 1993·Current Opinion in Neurobiology·S B McMahonP D Wall
Jul 14, 1997·Journal of the Autonomic Nervous System·P Callsen-Cencic, S Mense

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.