Release of silicone oil droplets from syringes

International Journal of Retina and Vitreous
Gustavo Barreto MeloMauricio Maia

Abstract

Intravitreal silicone oil droplets have been found in the vitreous. The aim of this study is to compare the rates of silicone oil released by different brands of commonly used syringes for intravitreal injection after agitation by flicking. Three models of two brands of syringes were analyzed for their rates of silicone oil release: Saldanha Rodrigues (SR) 1 mL insulin syringe (SR, Brazil, syringe 1), Becton-Dickinson (BD) Plastipak 1 mL insulin syringe (Brazil, syringe 2), and BD Safety-Glide 1 mL insulin syringe (USA, syringe 3). All syringes were tested under four different conditions: positive control (fluid with addition of silicone oil) without agitation (group 1, n = 5); positive control with agitation (group 2, n = 3); fluid only without agitation (group 3, n = 5); and fluid only with agitation (group 4, n = 5). Masked graders performed all analyses using light microscopy. All syringes (1, 2, and 3) released silicone oil droplets in the positive control group regardless of the agitation status (groups 1 and 2). When no oil was added and the syringes were not agitated, only syringe 1 released silicone oil droplets (40% of samples). After agitation, syringes 1 and 3 released silicone oil droplets in all samples. Quantitat...Continue Reading

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Citations

Mar 27, 2019·The British Journal of Ophthalmology·Gustavo Barreto MeloRubens Belfort
Sep 19, 2019·International Journal of Retina and Vitreous·Gustavo Barreto MeloMaurício Maia
Mar 5, 2020·Eye·Celso de Souza Dias JúniorGustavo Barreto Melo
Apr 8, 2020·Clinical Ophthalmology·Marc Schargus, Andreas Frings
Apr 21, 2020·Progress in Retinal and Eye Research·Gustavo Barreto MeloEduardo Büchele Rodrigues
Mar 10, 2021·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·Lukas Bisorca-GassendorfAnnekatrin Rickmann
Sep 22, 2020·Retina·Susan M DounceRoger A Goldberg
May 9, 2021·International Journal of Retina and Vitreous·William J AndersonGustavo Barreto Melo
May 25, 2021·European Journal of Ophthalmology·Natasha Ferreira Santos da CruzGustavo Barreto Melo

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