Release profile characteristics of biodegradable-polymer-coated drug particles fabricated by dual-capillary electrospray

Journal of Controlled Release : Official Journal of the Controlled Release Society
Yi-Hsuan LeeDa-Ren Chen

Abstract

This study describes one-step synthesis of coated particles by a dual-capillary electrospray (ES) system to produce monodisperse PLGA-coated drug particles. Different from a single-capillary ES system, the dual-capillary ES system separates drug and coating material, i.e., PLGA, solutions in two separate flow channels formed by two co-axially aligned capillaries and produce particles with the core(drug)-shell(PLGA) structure. No emulsion process is involved in the ES process. Our study shows that the studies system can achieve nearly 100% drug encapsulation efficiency with the proper system setting. Through the variation of PLGA concentration and the electrical conductivity of spray solutions, monodisperse PLGA-coated drug particles with sizes ranging from 165nm to 1.2microm were prepared. The drug release rates of prepared particles show that the small particles released the drug more rapidly than large ones. The SEM images of different release timing also show that the penetration of water into particles increases with the decrease of particle size, resulting in the fast particle swelling and eventually rupturing. This result demonstrates that the drug release profile can be controlled by tuning the particle size. We also obs...Continue Reading

Citations

Oct 12, 2012·Journal of Materials Science. Materials in Medicine·Oksan Karal-YilmazTurker Kilic
Sep 24, 2011·Langmuir : the ACS Journal of Surfaces and Colloids·Wenjie LiuXiao Dong Chen
Apr 27, 2012·Journal of the Royal Society, Interface·Adam BohrEleanor Stride
Aug 27, 2013·International Journal of Nanomedicine·Maedeh ZamaniSeeram Ramakrishna
Jul 19, 2014·Integrative Biology : Quantitative Biosciences From Nano to Macro·Shuting ZhaoXiaoming He
Dec 20, 2012·Expert Review of Medical Devices·Leilei ZhangRonald X Xu
Aug 15, 2014·Journal of Pharmaceutical Sciences·Yang CaoDeshuai Lou
Dec 22, 2015·International Journal of Pharmaceutics·Feng Wan, Mingshi Yang
Mar 3, 2015·Langmuir : the ACS Journal of Surfaces and Colloids·Wynter J DuncansonKatia Bertoldi
Feb 15, 2011·International Journal of Pharmaceutics·Konstantinos N KontogiannopoulosVassilios P Papageorgiou
Jan 25, 2011·International Journal of Pharmaceutics·Van-Thanh TranMarie-Claire Venier-Julienne
Sep 18, 2010·Colloids and Surfaces. B, Biointerfaces·Yi-Hsuan LeeDa-Ren Chen
Jul 26, 2012·Macromolecular Rapid Communications·Jeong Hoon ByeonJeffrey T Roberts
May 18, 2011·Biotechnology Progress·Mariana B Oliveira, João F Mano
Jul 16, 2015·Journal of Agricultural and Food Chemistry·Chen TanShuqin Xia
Oct 8, 2013·Materials Science & Engineering. C, Materials for Biological Applications·Shilei HaoJunyu Liu
May 6, 2015·Journal of Agricultural and Food Chemistry·José A Tapia-HernándezFrancisco Rodríguez-Félix
Sep 20, 2012·International Journal of Pharmaceutics·Thuy Thi Thu NguyenJun Seo Park
Dec 9, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Pooya DavoodiChi-Hwa Wang
Dec 19, 2013·Chemical Engineering Science·Qingxing XuChi-Hwa Wang
May 18, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Maryam ParhizkarMohan Edirisinghe
Jun 12, 2016·Journal of Pharmaceutical Sciences·Duong Nhat NguyenGuy Van den Mooter
Nov 6, 2015·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wing P ChanMeng-Yi Bai
Oct 10, 2018·Artificial Cells, Nanomedicine, and Biotechnology·Pankaj DwivediRonald X Xu
Oct 11, 2017·Journal of Biomaterials Science. Polymer Edition·Mei ZhangDahui Sun
Oct 4, 2018·AAPS PharmSciTech·Jorge Alberto S MorenoLine Hagner Nielsen

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