Releasing or expression modulating mediator involved in hemostasis by Berythractivase and Jararhagin (SVMPs)

Toxicon : Official Journal of the International Society on Toxinology
Agostinho Luiz Maia PereiraAna Marisa Chudzinski-Tavassi

Abstract

PIII snake venom metalloproteases (SVMPs) are structurally related to ADAMs (a disintegrin and metalloprotease human family of proteins). Berythractivase and Jararhagin are PIII SVMPs with 69% homology with different hemostatic properties. In order to clarify these differences and further characterize the biological effects of these proteins, we compared the effect of both proteases on human umbilical vein endothelial cell (HUVEC) for evaluating the release and modulation of coagulation and fibrinolysis mechanisms as well as the expression of their correlated genes. We found that both proteins increase the von Willebrand factor liberation, but did not modulate gene expression. Berythractivase, differently from Jararhagin increased the expression of tissue factor. Our results showed that both SVMPs (Berythractivase and Jararhagin) activate HUVEC releasing or modulating mediators involved in hemostasis. Meanwhile, we can suggest through the up-regulation of TF gene that the studied SVMP acts in a specific manner, suggesting that Jararhagin has preferentially a local action, while Berythractivase can be assumed as a systemic pro-coagulant protein with activity on the surface of HUVECs.

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Citations

Jul 9, 2016·Toxicon : Official Journal of the International Society on Toxinology·María Elisa Peichoto, Marcelo Larami Santoro
Dec 22, 2016·Revista Da Sociedade Brasileira De Medicina Tropical·Neriane Monteiro NeryJuliana Pavan Zuliani
Sep 26, 2020·Frontiers in Immunology·Irmgardt Alicia María WellmannAllyson Guimarães Costa
Oct 2, 2019·Frontiers in Immunology·Catarina TeixeiraAna Marisa Chudzinski-Tavassi
Dec 10, 2019·International Journal of Biological Macromolecules·G N CezaretteS V Sampaio

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