Relevance of antifungal penetration in biofilm-associated resistance of Candida albicans and non-albicans Candida species

Journal of Medical Microbiology
Rachna SinghArunaloke Chakrabarti

Abstract

The role of penetration limitation in Candida biofilm-associated antifungal resistance remains unclear. Most of the previous work has been done on Candida albicans, although non-albicans (NAC) species are also implicated in invasive candidiasis and the biofilm matrix has been shown to vary amongst different species. Only a few studies have evaluated clinical isolates. This study aimed to determine the relevance of penetration limitation in the antifungal resistance of biofilms formed by C. albicans and NAC clinical isolates, using an agar disk diffusion assay. The penetration of posaconazole and amphotericin B through the biofilms was significantly reduced. Fluconazole, voriconazole and caspofungin showed a superior penetration capacity in C. albicans, Candida tropicalis and Candida parapsilosis biofilms, but exhibited inter-species and strain/isolate variation. Candida krusei biofilms were the most resilient to antifungal permeation. All of the antifungal drugs failed to kill the biofilm cells, independent of penetration, suggesting that the other factors contribute markedly to the recalcitrance of the biofilms.

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Citations

Jun 4, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Giovanna SimonettiGabriella Pasqua
May 15, 2020·Medical Mycology·Rocío Sánchez-HerreraJulio Cesar Villagómez-Castro
Oct 28, 2019·Critical Reviews in Food Science and Nutrition·Rosanna TofaloCharles M A P Franz
Oct 13, 2020·Frontiers in Microbiology·Noel Vera-González, Anita Shukla
Aug 7, 2021·Critical Reviews in Microbiology·Maryam RoudbaryCélia F Rodrigues
Oct 12, 2021·Antimicrobial Agents and Chemotherapy·Suresh AmbatiRichard B Meagher

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