Relevance of chronic stress and the two faces of microglia in Parkinson's disease

Frontiers in Cellular Neuroscience
Antonio J HerreraJosé L Venero

Abstract

This review is aimed to highlight the importance of stress and glucocorticoids (GCs) in modulating the inflammatory response of brain microglia and hence its potential involvement in Parkinson's disease (PD). The role of inflammation in PD has been reviewed extensively in the literature and it is supposed to play a key role in the course of the disease. Historically, GCs have been strongly associated as anti-inflammatory hormones. However, accumulating evidence from the peripheral and central nervous system have clearly revealed that, under specific conditions, GCs may promote brain inflammation including pro-inflammatory activation of microglia. We have summarized relevant data linking PD, neuroinflamamation and chronic stress. The timing and duration of stress response may be critical for delineating an immune response in the brain thus probably explain the dual role of GCs and/or chronic stress in different animal models of PD.

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Citations

Dec 30, 2015·Acta Neuropathologica·Nevenka Dudvarski StankovicMirko H H Schmidt
Nov 12, 2015·Biochemical Pharmacology·Mithilesh Kumar JhaKyoungho Suk
Jan 19, 2016·Frontiers in Cellular Neuroscience·Bruno Di Marco VieiraDean L Pountney
Dec 14, 2016·Annual Review of Physiology·Susanne A WolfHelmut Kettenmann
Mar 20, 2018·Molecular Brain·Ernest Dallé, Musa V Mabandla
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Mar 18, 2017·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Zidan ZhaoFrederick R Walker
May 24, 2017·Cellular and Molecular Neurobiology·John Alimamy KabbaTao Pang
Jul 22, 2017·Frontiers in Aging Neuroscience·Ana I RamirezJosé M Ramírez
Apr 6, 2018·Frontiers in Cellular Neuroscience·Stephen D SkaperPietro Giusti
Jul 22, 2018·Frontiers in Aging Neuroscience·Ana I ArrobaÁngela M Valverde
Nov 7, 2020·Molecular Psychiatry·Orly ReinerArpan Parichha

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BETA
ubiquitination
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