Relevance of coronary microvascular flow impairment to long-term remodeling and systolic dysfunction in hypertrophic cardiomyopathy

Journal of the American College of Cardiology
Iacopo OlivottoPaolo G Camici

Abstract

This study sought to evaluate whether the entity of microvascular dysfunction, assessed by positron emission tomography (PET), predicts the long-term development of left ventricular (LV) remodeling and systolic dysfunction in hypertrophic cardiomyopathy (HCM). A subgroup of patients with HCM developed LV dilation and systolic impairment. A causal role of coronary microvascular dysfunction has been suggested as the underlying pathophysiological mechanism. Fifty-one patients (New York Heart Association functional class I to II) were followed up for 8.1 +/- 2.1 years after measurement of resting and dipyridamole (Dip) myocardial blood flow (MBF). Left ventricular systolic dysfunction was defined as an ejection fraction (LVEF) <50%. The Dip-MBF was blunted in HCM patients compared with a group of healthy control patients (1.50 +/- 0.69 ml/min/g vs. 2.71 +/- 0.94 ml/min/g; p < 0.001). At final evaluation, 11 patients (22%) had an LVEF <50%; in most (n = 7), systolic dysfunction was associated with a significant increase in LV cavity dimensions (>5 mm) during follow-up. These 11 patients showed lower Dip-MBF than the 40 with preserved LV function (1.04 +/- 0.38 ml/min/g vs. 1.63 +/- 0.71 ml/min/g, respectively; p = 0.001); Dip-MBF wa...Continue Reading

References

Sep 1, 1986·Journal of the American College of Cardiology·B J MaronW C Roberts
Aug 15, 1994·The American Journal of Cardiology·R GistriP G Camici
Aug 1, 1993·The American Journal of Cardiology·B J MaronF Cecchi
Apr 15, 1997·The American Journal of Cardiology·T InoN Sueyoshi
Jan 24, 2003·The New England Journal of Medicine·Martin S MaronBarry J Maron
Jun 14, 2003·Journal of the Renin-angiotensin-aldosterone System : JRAAS·Jean-Jacques MouradMichel E Safar
Sep 4, 2003·Circulation·Raffaella LombardiMassimo Chiariello
Sep 12, 2003·The New England Journal of Medicine·Franco CecchiPaolo G Camici

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Citations

Jul 7, 2007·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·M J KofflardP W Serruys
Sep 3, 2009·Current Heart Failure Reports·Alyson Kelley-Hedgepeth, Martin S Maron
Jun 19, 2010·Journal of Cardiovascular Translational Research·Martin S Maron
Jun 19, 2010·Journal of Cardiovascular Translational Research·Iacopo OlivottoMagdi H Yacoub
Jun 19, 2010·Journal of Cardiovascular Translational Research·Franco CecchiIacopo Olivotto
Jan 20, 2009·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Roberto SciagràAlberto Pupi
Jun 17, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Maria Cecilia Ziadi, Rob S B Beanlands
Jun 3, 2008·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Rory O'HanlonDudley J Pennell
Apr 26, 2007·Nature Clinical Practice. Cardiovascular Medicine·Magdi H YacoubFranco Cecchi
Feb 23, 2007·The New England Journal of Medicine·Paolo G Camici, Filippo Crea
Aug 24, 2012·European Heart Journal·Joerg HerrmannAmir Lerman
Mar 21, 2012·Circulation·Carolyn Y Ho
Feb 3, 2012·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Martin S Maron
Nov 28, 2006·Circulation Journal : Official Journal of the Japanese Circulation Society·Hiroaki KitaokaYoshinori L Doi
Jun 21, 2014·Seminars in Nuclear Medicine·Mark I Travin
Oct 24, 2014·Radiology·Jan Bogaert, Iacopo Olivotto
Apr 29, 2010·Current Cardiology Reports·Thomas E VanheckePeter A McCullough
Feb 6, 2016·European Journal of Nuclear Medicine and Molecular Imaging·Roberto SciagràUNKNOWN Cardiovascular Committee of the European Association of Nuclear Medicine (EANM)
Mar 1, 2014·The American Journal of Cardiology·Travis J MossJoseph L Schuller
Jul 23, 2013·The American Journal of Cardiology·Rossella D'AmatoIacopo Olivotto
Jan 24, 2016·The American Journal of the Medical Sciences·Yan XiaoJian-Jun Li
May 7, 2013·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Milorad TesicBosiljka Vujisic-Tesic
Aug 29, 2012·Medical Hypotheses·Qixia JiangChun Liang
Sep 20, 2011·Journal of Molecular and Cellular Cardiology·Paolo G CamiciOrnella E Rimoldi
Jun 1, 2011·Journal of Cardiac Failure·Hirotaka KawaraiHiroshi Kasanuki
May 10, 2011·Journal of Cardiac Failure·Giovanni Donato AquaroMassimo Lombardi
Mar 25, 2009·Cardiology Clinics·Heinrich R Schelbert
Jul 2, 2011·Annals of the New York Academy of Sciences·Palak ShahRamesh Mazhari
Jul 3, 2013·European Journal of Heart Failure·Benedetta TomberliIacopo Olivotto
Dec 20, 2014·Journal of the American College of Cardiology·Raffaele CoppiniIacopo Olivotto
Jan 28, 2010·The American Journal of Cardiology·Kevin S HeffernanJeffrey T Kuvin
Jun 27, 2015·The Canadian Journal of Cardiology·Ling ZhuLei Song
Jul 24, 2007·International Journal of Cardiology·Paola MelaciniSabino Iliceto
Aug 10, 2012·Lancet·Barry J Maron, Martin S Maron
May 30, 2015·Chinese Medical Journal·Yan XiaoXian-Liang Zhou
Jul 3, 2007·Journal of the American College of Cardiology·Ning CheungTien Yin Wong
Aug 13, 2011·Journal of the American College of Cardiology·Iacopo OlivottoFranco Cecchi
Apr 3, 2010·Journal of the American College of Cardiology·Francesca GirolamiIacopo Olivotto

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