PMID: 12788407Jun 6, 2003Paper

Relevance of DNA methylation in the management of cancer

The Lancet Oncology
Manel Esteller

Abstract

Many genetic and environmental factors contribute to development of cancer, but DNA methylation may provide a link between these influences. Genome stability and normal gene expression are largely maintained by a fixed and predetermined pattern of DNA methylation. In cancer, this idealistic scenario is disrupted by an interesting phenomenon: the hypermethylation of regulatory regions called CpG islands in some tumour suppressor genes--eg, BRCA1, hMLH1, p16INK4a, APC, VHL--which causes their inactivation. Development of new techniques that couple bisulphite modification with PCR has enabled these alterations to be studied in all types of biological fluids and archived tissues. Potentially, there are four types of translational studies that can be used to investigate the aberrant pattern of DNA methylation in cancer. First, CpG island hypermethylation can be used as a marker to identify cancer cells from biological samples, eg, serum and urine. This technique is highly sensitive and informative because profiles of tumour-suppressor-gene inactivation are specific to particular cancers. Second, single and combined genes that are inactivated by promoter hypermethylation, such as p16INK4a and DAPK, can be used as prognostic factors. ...Continue Reading

References

Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Aug 1, 1997·Trends in Genetics : TIG·J A YoderT H Bestor
Jun 17, 1998·Proceedings of the National Academy of Sciences of the United States of America·J G HermanS B Baylin
Mar 2, 1999·Journal of the National Cancer Institute·S A AhrendtD Sidransky
Nov 7, 1999·The American Journal of Pathology·M EstellerJ G Herman
Apr 6, 2000·Journal of the National Cancer Institute·M EstellerJ G Herman
Aug 17, 2000·Journal of the National Cancer Institute·A K VirmaniA F Gazdar
Nov 18, 2000·Journal of the National Cancer Institute·K KawakamiS J Meltzer
Mar 21, 2001·Human Molecular Genetics·S B BaylinJ G Herman
Mar 27, 2001·Nature Reviews. Genetics·K D Robertson, A P Wolffe
Dec 26, 2001·Human Molecular Genetics·M EstellerJ G Herman
Mar 16, 2002·European Journal of Human Genetics : EJHG·Christoph Plass, Paul D Soloway
May 1, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Stanton L Gerson
Jul 16, 2002·Carcinogenesis·Esteban Ballestar, Manel Esteller
Sep 17, 2002·Science·Manel EstellerJames G Herman
Feb 7, 2003·Current Drug Metabolism·Ana Villar-Garea, Manel Esteller

❮ Previous
Next ❯

Citations

Sep 24, 2004·International Journal of Cancer. Journal International Du Cancer·Masaaki YanoNobuyoshi Shimizu
Aug 3, 2005·Journal of Cancer Research and Clinical Oncology·Hee Cheol KimRin Chang
Jul 1, 2006·Journal of Cancer Research and Clinical Oncology·Carsten KempkensteffenMark Schrader
Jun 2, 2005·Human Genetics·Barbara SarterPeter W Laird
Apr 29, 2009·Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban·Shilong ZhangLiang Wang
Jan 26, 2011·Medical Oncology·Kaixiong TaoGuobin Wang
Jan 8, 2013·Medical Oncology·Wenjiao ChenPing Liu
Nov 10, 2012·Archives of Pharmacal Research·Hak Jae KimBeom Soo Shin
Jun 1, 2005·Cancer Letters·Barbara BanelliMassimo Romani
Oct 31, 2003·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Manel Esteller
May 22, 2004·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marina I GutiérrezKishor Bhatia
Sep 18, 2007·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Marloes BerkhoutJudith W M Jeuken
Nov 30, 2006·Immunology and Cell Biology·A E Germenis, V Karanikas
Feb 16, 2012·Antioxidants & Redox Signaling·Anna LyYoung-In Kim
Jul 24, 2008·Annals of Oncology : Official Journal of the European Society for Medical Oncology·K P M SuijkerbuijkP J van Diest
Dec 27, 2005·Carcinogenesis·M Matabuena de YzaguirreJ Fernández-Piqueras
Aug 19, 2004·Journal of the National Cancer Institute·Miguel AlaminosManel Esteller
Oct 20, 2005·Journal of the National Cancer Institute·Frank Lyko, Robert Brown
Apr 28, 2007·The Cancer Journal·Bodo BruecknerFrank Lyko
Jun 6, 2009·Genome Research·Yasuo KogaSherman M Weissman
May 23, 2012·Genome Research·Suhaida A SelamatIte A Laird-Offringa
Feb 15, 2013·Gut·Timothy Robert ChurchUNKNOWN PRESEPT Clinical Study Steering Committee, Investigators and Study Team
Nov 16, 2010·Genome Génome / Conseil National De Recherches Canada·Graham J KingSmita Kurup
Apr 12, 2005·Annual Review of Pharmacology and Toxicology·Manel Esteller
Jun 3, 2004·The Journal of Clinical Investigation·Irma AiroldiVito Pistoia
Mar 5, 2009·BMC Medical Genomics·Ada PiepoliAngelo Andriulli
Feb 5, 2008·Breast Cancer Research : BCR·Mollie H WrightLyuba Varticovski
Jun 23, 2010·Breast Cancer Research : BCR·Karolina HolmMarkus Ringnér

❮ Previous
Next ❯

Related Concepts

Related Feeds

Breast Cancer: BRCA1 & BRCA2

Mutations involving BRCA1, found on chromosome 17, and BRCA2, found on chromosome 13, increase the risk for specific cancers, such as breast cancer. Discover the last research on breast cancer BRCA1 and BRCA2 here.

Related Papers

Annual Review of Pharmacology and Toxicology
Manel Esteller
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
Manel Esteller
Clinical Immunology : the Official Journal of the Clinical Immunology Society
Manel Esteller
© 2022 Meta ULC. All rights reserved