Relevance of dopamine D(2)/neurotensin NTS1 and NMDA/neurotensin NTS1 receptor interaction in psychiatric and neurodegenerative disorders

Current Medicinal Chemistry
Sergio TanganelliLuca Ferraro

Abstract

The existence of functional NT/dopamine interactions in the central nervous system has been extensively documented. Among others, a possible molecular mechanism underlying the NT-induced modulation of dopamine release is a direct antagonistic NTS(1)/D(2) receptor interaction. More recently, neurochemical experiments also supported the existence of a possible interaction between NT and N-methyl-d-aspartate (NMDA) receptors. In particular, it has been suggested that NT, by amplifying NMDA receptor signaling, could be involved in neurodegeneration. The present article attempts to provide a summary of current knowledge, mainly emerging from our studies, on the existence of receptor-receptor interactions between NT receptor subtype 1 (NTS1) and dopamine D(2) or NMDA receptors in the brain. Special emphasis is placed on the pre and post-synaptic neurochemical mechanisms possibly underlying the involvement of these interactions in the physiopathology of schizophrenia and acute neurodegenerative disorders.

Citations

Jan 13, 2016·Journal of Psychopharmacology·Luca FerraroMalgorzata Filip
Mar 9, 2017·Frontiers in Cellular Neuroscience·Dasiel O Borroto-EscuelaKjell Fuxe
Jul 17, 2015·Journal of Neurophysiology·Katherine Stuhrman, Aaron G Roseberry
Sep 21, 2021·Epilepsia Open·Daniel Fonseca-BarriendosLuisa Rocha

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