PMID: 11316105Apr 24, 2001Paper

Relevance of dyspnoea and respiratory function measurements in monitoring of asthma: a factor analysis

Respiratory Medicine
M GrazziniN Ambrosino

Abstract

Previous studies in patients with stable chronic obstructive pulmonary disease have demonstrated that objective measures (lung volumes and respiratory muscle force) and clinical or subjective measures (symptoms of breathlessness and exercise tolerance) are quantities that independently characterize the conditions of these patients. Such an evaluation has not been previously applied in patients with stable bronchial asthma. Sixty-nine patients with stable chronic asthma underwent evaluation of static (functional residual capacity, FRC) and dynamic [forced expiratory volume in 1 sec (FEV1) and forced vital capacity, FVC] lung volumes; respiratory muscle strength (RMS), by measuring maximal inspiratory and expiratory pressures, and exercise capacity by means of the 6-min walking distance (6MWD). Chronic exertional dyspnoea was assessed by the Baseline Dyspnoea Index (BDI) focal score and by the Medical Research Council (MRC) scale. Statistical evaluation was performed by applying factor analysis. Three factors accounted for 78% of the total variance in the data: FEV1, FVC loaded on a factor I; RMS, FRC and 6MWD loaded on a factor II; dyspnoea ratings loaded on a factor III. Post-hoc analysis by randomly dividing the patients into ...Continue Reading

Citations

Oct 3, 2003·American Journal of Respiratory and Critical Care Medicine·E R McFadden
May 29, 2007·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Carol A MancusoMary E Charlson
Jun 16, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Jason WeatheraldGilles Garcia
Aug 12, 2016·Pulmonary Therapy·Matea DeliuAdnan Custovic
Jun 5, 2002·Current Opinion in Allergy and Clinical Immunology·Peter G Gibson
Jan 8, 2008·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S G PillaiP J Helms
Oct 8, 2016·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Francois VermeulenVincent Ninane
Jun 19, 2009·American Journal of Respiratory and Critical Care Medicine·Helen K ReddelUNKNOWN American Thoracic Society/European Respiratory Society Task Force on Asthma Control and Exacerbations

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