Relevance of endothelium-derived hyperpolarizing factor in the effects of hypertension on rat coronary relaxations

Journal of Hypertension
S Vázquez-PérezV Lahera

Abstract

To evaluate the relative participation of nitric oxide (NO), endothelium-derived hyperpolarizing factor (EDHF) and prostanoids in the relaxing responses induced by acetylcholine and isoproterenol in isolated coronary arteries from adult Wistar- Kyoto (WKY) rats and spontaneously hypertensive rats (SHR). Male adult WKY rats and SHR were used in the study. Segments from left coronary arteries (approximately 350-380 microm internal diameter and 2 mm long) were mounted in an isometric myograph and pre-contracted with serotonin. Dose-response curves to acetylcholine and isoproterenol were carried out in absence and presence of the NO synthesis inhibitor NG-nitro-L-arginine methyl ester (LNAME), the inhibitor of the cyclo-oxygenase, indomethacin and KCI. Areas under the respective dose-response curves were used to calculate the approximate relative participation of NO, EDHF and prostanoids. Relaxations to either acetylcholine or isoproterenol were lower in SHR than in WKY rats. In WKY rats, presence of LNAME diminished (P< 0.05) relaxation to acetylcholine from 10(-9) to 10(-6) mol/l, and induced a contracting response at 10(-5) and 10(-4) mol/l of acetylcholine. Addition of indomethacin did not significantly affect dose-related rela...Continue Reading

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Citations

Dec 3, 2008·Journal of Physiology and Biochemistry·R Aras-LópezG Balfagón
Mar 18, 2004·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Michel Félétou, Paul M Vanhoutte
Jul 28, 2010·Clinical and Experimental Pharmacology & Physiology·Satomi KagotaKazumasa Shinozuka
Jan 9, 2010·Vascular Health and Risk Management·Andrew S LevyJames W E Rush
Jul 29, 2008·Atherosclerosis·Leanid LukshaKarolina Kublickiene
Aug 1, 2015·Journal of Molecular and Cellular Cardiology·Gisele K CoutoLuciana V Rossoni
Jun 3, 2016·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Begoña Quintana-VillamandosMaría Carmen González
Jan 25, 2018·International Journal of Molecular Sciences·Kenichi GotoTakanari Kitazono
Aug 17, 2004·American Journal of Physiology. Heart and Circulatory Physiology·David Sanz-RosaVictoria Cachofeiro
Apr 25, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Michel Félétou, Paul M Vanhoutte
Jan 16, 2007·American Journal of Physiology. Heart and Circulatory Physiology·Marta FocardiWilliam M Chilian
Aug 17, 2014·American Journal of Physiology. Heart and Circulatory Physiology·Christian SchachDierk H Endemann
Nov 2, 2019·Basic & Clinical Pharmacology & Toxicology·Hui ChenSusan Wai Sum Leung
May 31, 2019·Animals : an Open Access Journal From MDPI·Luisauris JaimesJosé L Martínez
May 31, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eva CedielVicente Lahera
Aug 17, 2018·Journal of Molecular and Cellular Cardiology·T D PaulaL M Bendhack

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