Relevance of genetic polymorphisms in inflammatory response to percutaneous coronary intervention

Scandinavian Journal of Clinical and Laboratory Investigation
Nawzad SalehPer Tornvall

Abstract

It has recently been reported that inflammatory markers, such as C-reactive protein (CRP) and interleukin-6 (IL-6), increase in plasma as a response to the stimulus of percutaneous coronary intervention (PCI). The magnitude of this inflammatory response is associated with the risk of restenosis. There is a large inter-individual variation in the inflammatory response to PCI. One factor shown to be of importance is stent implantation but the reasons for the variation are to a large extent unknown. One possible reason could be genetic variation in the regulation of CRP and IL-6 levels. One functional single nucleotide polymorphism (SNP) located at position -286 in the promoter region of the CRP gene associated with plasma CRP levels has recently been described. Another SNP located at -174 in the promoter region of the IL-6 gene has been associated with plasma IL-6 concentration. The hypothesis behind the present study was that the SNPs CRP -286 and IL-6 -174 were associated with the inflammatory response to PCI, including stent implantation. The results did not show any association with plasma levels of CRP and IL-6 measured as area-under-curve up to 72 hours after PCI indicating that genetic variation is unlikely to play a major...Continue Reading

References

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Citations

Nov 23, 2010·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Marie BennermoPer Tornvall

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