PMID: 7545818Jul 1, 1995Paper

Relevance of mediators to cardiac parameters of isolated anaphylactic guinea-pig heart

Prostaglandins, Leukotrienes, and Essential Fatty Acids
H J MestC Giessler

Abstract

The release of histamine, eicosanoids and catecholamines were measured after induction of anaphylaxis in isolated guinea-pig hearts. The concentration-time profile of these mediators was compared with changes of cardiac parameters. The histamine and catecholamine levels of the coronary effluent were determined at 10 s intervals; thromboxane and prostacyclin levels at 60 s intervals. The release of histamine and norepinephrine were maximum between 20 and 30 s after the antigen challenge and decreased rapidly within 60 s. Thromboxane and prostacyclin increased to a maximum after 3 min and declined slowly within 10 min. The rise in histamine release was correlated with tachycardia. The release of thromboxane was correlated with the increase of coronary perfusion pressure. Cimetidine inhibited the tachycardia and clemastine reduced bradyarrhythmia. The inhibition of lipoxygenase and cyclooxygenase also reduced the rise in the perfusion pressure. These data suggest that different mediators are time-dependently involved in anaphylaxis-induced cardiac changes.

References

Jun 1, 1990·Journal of Cardiovascular Pharmacology·S B FelixW E Berdel
Jul 1, 1990·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·H J MestT Rein
Jan 1, 1986·Circulation Research·A A Wolff, R Levi
Dec 2, 1988·Journal of Chromatography·K S BoosR Sauerbrey
Oct 1, 1987·Journal of Molecular and Cellular Cardiology·J R ParrattC L Wainwright
Jul 1, 1974·European Journal of Pharmacology·Z S ErcanR K Türker
Nov 1, 1981·Prostaglandins and Medicine·H J Mest, W Förster

❮ Previous
Next ❯

Citations

May 5, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·R C Braun-DullaeusW Haberbosch
Dec 19, 2007·International Archives of Allergy and Immunology·Seiichiro KanoRoberto Levi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Bradyarrhythmias

Bradyarrhythmias are slow heart rates. Symptoms may include syncope, dizziness, fatigure, shortness of breath, and chest pains. Find the latest research on bradyarrhythmias here.

Anaphylaxis

Anaphylaxis is a serious allergic reaction that is rapid in onset and may cause death.