Relevance of micrometastases detected by reverse transcriptase-polymerase chain reaction for melanoma recurrence: systematic review and meta-analysis

São Paulo Medical Journal = Revista Paulista De Medicina
Allisson Monteiro da SilvaHumberto Saconato

Abstract

Cutaneous melanoma presents significant morbidity and mortality. Nowadays, about 90% of them are diagnosed by clinical examination and most are localized melanomas. Sentinel node biopsy has brought about a new and interesting approach towards localized cutaneous melanoma. The meaning of micrometastases in sentinel nodes diagnosed by the reverse transcriptase-polymerase chain reaction is not well established. To define the real value of micrometastases diagnosed by the reverse transcriptases polymerase chain reaction in relation to melanoma recurrence. Systematic literature review and meta-analysis. The Cochrane Library, Medline, Embase and Lilacs were the databases searched. We used the following key words: sentinel node and melanoma; sentinel node and reverse transcriptase-polymerase chain reaction; melanoma and reverse transcriptase-polymerase chain reaction. Cohort studies enrolling localized cutaneous melanoma patients who underwent sentinel node biopsy were selected. Sentinel node evaluations included hematoxylin and eosin, immunohistochemistry and reverse transcriptase-polymerase chain reaction. Out of the 1,542 studies evaluated, four were eligible. The four studies, when combined, were statistically homogeneous. The sam...Continue Reading

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May 17, 2007·Annals of Surgical Oncology·Charles CoutantEmmanuel Barranger
Oct 22, 2008·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Eduardo B CândidoPaulo Traiman
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Apr 24, 2010·Revista do Colégio Brasileiro de Cirurgiões·Renato Santos de Oliveira FilhoRenan Gianotto de Oliveira

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