Relevance of Multi-Omics Studies in Cardiovascular Diseases

Frontiers in Cardiovascular Medicine
Paola Leon-MimilaAdriana Huertas-Vazquez

Abstract

Cardiovascular diseases are the leading cause of death around the world. Despite the larger number of genes and loci identified, the precise mechanisms by which these genes influence risk of cardiovascular disease is not well understood. Recent advances in the development and optimization of high-throughput technologies for the generation of "omics data" have provided a deeper understanding of the processes and dynamic interactions involved in human diseases. However, the integrative analysis of "omics" data is not straightforward and represents several logistic and computational challenges. In spite of these difficulties, several studies have successfully applied integrative genomics approaches for the investigation of novel mechanisms and plasma biomarkers involved in cardiovascular diseases. In this review, we summarized recent studies aimed to understand the molecular framework of these diseases using multi-omics data from mice and humans. We discuss examples of omics studies for cardiovascular diseases focused on the integration of genomics, epigenomics, transcriptomics, and proteomics. This review also describes current gaps in the study of complex diseases using systems genetics approaches as well as potential limitation...Continue Reading

References

Apr 14, 1994·The New England Journal of Medicine·M E MarenbergU de Faire
Sep 25, 2002·Journal of Internal Medicine·S ZdravkovicU De Faire
Apr 24, 2004·Arteriosclerosis, Thrombosis, and Vascular Biology·Nicholas L M CrudenDavid E Newby
May 5, 2007·Science·Anna HelgadottirKari Stefansson
May 5, 2007·Science·Ruth McPhersonJonathan C Cohen
Jul 20, 2007·The New England Journal of Medicine·Nilesh J SamaniUNKNOWN WTCCC and the Cardiogenics Consortium
Jan 15, 2008·Nature Genetics·Cristen J WillerGonçalo R Abecasis
Mar 18, 2008·Nature·Valur EmilssonKari Stefansson
Jul 24, 2008·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Nilesh J SamaniMartin D Tobin
Nov 27, 2008·Journal of Lipid Research·Sulin WuThomas A Drake
Feb 10, 2009·Nature Genetics·UNKNOWN Myocardial Infarction Genetics ConsortiumDavid Altshuler
Jul 14, 2009·Arteriosclerosis, Thrombosis, and Vascular Biology·Olga JarinovaRuth McPherson
Jan 6, 2010·Circulation·Aldons J Lusis, James N Weiss
Aug 6, 2010·Nature·Tanya M TeslovichSekar Kathiresan
Jan 27, 2011·PLoS Biology·Naomi R WrayPeter M Visscher
Mar 8, 2011·Nature Genetics·UNKNOWN Coronary Artery Disease (C4D) Genetics Consortium
Apr 5, 2011·American Journal of Human Genetics·Lutz P BreitlingHermann Brenner
Sep 3, 2011·Nature·Karsten SuhreChristian Gieger
Jan 11, 2012·Nature Reviews. Cardiology·W Robb MacLellanAldons J Lusis
Sep 8, 2012·Nature·UNKNOWN ENCODE Project Consortium
Dec 4, 2012·Nature Genetics·Panos DeloukasNilesh J Samani
May 30, 2013·Nature Genetics·UNKNOWN GTEx Consortium
Dec 4, 2013·Nature Reviews. Genetics·Mete Civelek, Aldons J Lusis
Aug 19, 2014·Lancet·Daniel J Rader, G Kees Hovingh
Aug 19, 2014·Lancet·Børge G Nordestgaard, Anette Varbo
Jan 13, 2015·Circulation. Cardiovascular Genetics·Hassan Foroughi AslUNKNOWN CARDIoGRAM Consortium
Feb 20, 2015·Nature·UNKNOWN Roadmap Epigenomics ConsortiumManolis Kellis
Aug 22, 2015·Arteriosclerosis, Thrombosis, and Vascular Biology·Ingrid BrænneUNKNOWN Leducq Consortium CAD Genomics‡
Dec 18, 2015·Circulation·UNKNOWN Writing Group MembersUNKNOWN Stroke Statistics Subcommittee
Jan 15, 2016·Nature Reviews. Cardiology·Donna K Arnett
Mar 5, 2016·The New England Journal of Medicine·UNKNOWN Myocardial Infarction Genetics and CARDIoGRAM Exome Consortia InvestigatorsHeribert Schunkert
Mar 17, 2016·Nature Reviews. Molecular Cell Biology·Caroline H JohnsonGary Siuzdak
May 3, 2016·Cell Systems·Husain A TalukdarJohan L M Björkegren
Jun 29, 2016·Genome Biology·Koen F DekkersBastiaan T Heijmans
Aug 9, 2016·Trends in Molecular Medicine·Rajendra Raghow

❮ Previous
Next ❯

Citations

Dec 6, 2019·Briefings in Bioinformatics·Bohdan B KhomtchoukThemistocles L Assimes
Oct 16, 2019·Journal of Clinical Pathology·Giuditta BenincasaClaudio Napoli
Aug 9, 2020·International Journal of Hypertension·Hao PengChangwei Li
Dec 5, 2019·International Journal of Molecular Sciences·Letizia ScolaCarmela Rita Balistreri
May 6, 2020·Journal of Cardiovascular Translational Research·Stefan MeierEmma Louise Robinson
Jul 28, 2020·Frontiers in Oncology·Marco ChiericiCesare Furlanello
Feb 11, 2020·Frontiers in Cardiovascular Medicine·Antonio de MarvaoDeclan P O'Regan
Aug 20, 2020·Circulation. Genomic and Precision Medicine·Saumya DasUNKNOWN American Heart Association Council on Genomic and Precision Medicine; Council on Arteriosclerosis, Thrombosis and Vascular B
Mar 3, 2020·Frontiers in Molecular Biosciences·Katarzyna PolonisMichał J Markuszewski
Aug 11, 2020·Current Atherosclerosis Reports·Amit Goyal, Leslie Cho
Feb 3, 2021·Cardiovascular Drugs and Therapy·E F MagavernM Pirmohamed
Mar 17, 2021·Briefings in Bioinformatics·Stephen DoranAdil Mardinoglu
Mar 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Min ZhouThomas Efferth
Nov 4, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Hao ZhangGavin Y Oudit
Apr 24, 2021·Journal of the American College of Cardiology·William M OldhamLei Xiao
May 9, 2021·Environmental Science and Pollution Research International·Thoria Donia, Abeer Khamis
Jun 3, 2021·International Journal of Molecular Sciences·Alejandro Junco-VicenteIsabel Rodríguez
Jun 21, 2021·Nanomedicine : Nanotechnology, Biology, and Medicine·Ruchita ShandilyaPradyumna Kumar Mishra
Jun 26, 2021·Frontiers in Immunology·Sonya KrishnanPetros C Karakousis
Jul 22, 2021·Computational and Structural Biotechnology Journal·Milan PicardArnaud Droit
Jul 10, 2021·Journal of the American College of Cardiology·Borja IbanezValentín Fuster
Aug 24, 2021·Frontiers in Physiology·Akram Tayanloo-BeikBagher Larijani
Aug 21, 2021·The Journal of Clinical Endocrinology and Metabolism·Alyssa ImbertArmand Valsesia
Nov 4, 2021·Current Heart Failure Reports·Dongqing ChenAaron L Sverdlov

❮ Previous
Next ❯

Methods Mentioned

BETA
exome array
immunoprecipitation

Software Mentioned

Encode
Roadmap
GTEx

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Related Papers

Frontiers in Cardiovascular Medicine
Tina HaaseTanja Zeller
Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Francesco Paolo SchenaSharon N Cox
© 2021 Meta ULC. All rights reserved