Relevance of progesterone receptor immunohistochemical staining to Oncotype DX recurrence score

Hematology/oncology and Stem Cell Therapy
Lubna N ChaudharyChristopher R Chitambar

Abstract

Progesterone-receptor negativity (PR-) is predictive of adverse outcomes in estrogen receptor-positive (ER+) breast cancer. The Oncotype DX assay provides risk stratification for hormone receptor-positive (HR+) invasive breast cancer; however, the association of PR status and Oncotype DX recurrence scores (RSs) is less clear. We designed an analysis to determine whether a significant difference exists in the RS for ER+/PR- tumors when compared with ER+/PR+ breast cancer. Three hundred and fifty patients with HR+ invasive breast cancer who underwent Oncotype DX testing at our institution from December 2006 to October 2013 were included. We also examined the concordance in the HR status reported by immunohistochemical (IHC) and reverse transcriptase-polymerase chain reaction (RT-PCR) analyses. The data were analyzed by analysis of variance, F test, t test, and chi-square tests. Multivariate linear regression was used to determine significant predictors of Oncotype DX RS. A total of 301 patients had ER+/PR+ tumors and 47 patients had ER+/PR- tumors by IHC. PR- tumors had a significantly higher RS than PR+ tumors (24.7±8.53 vs. 17.3±7.38; p<.001), predicting a greater 10-year risk of distant recurrence. Multivariate linear regressi...Continue Reading

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Citations

Nov 20, 2016·Revista española de medicina nuclear e imagen molecular·G K GedikO Sari
Sep 20, 2018·The Breast Journal·Parker C WilsonMalini Harigopal
Sep 10, 2018·Breast Cancer Research and Treatment·Jing Li HuangJane Yuet Ching Hui
Mar 1, 2017·Breast Cancer Research and Treatment·Amila OrucevicRobert E Heidel
Jul 30, 2020·Annals of Surgical Oncology·Christine DauphineJunko Ozao-Choy
May 23, 2019·Cancer Research·Indira PrabakaranMarina A Guvakova
Feb 10, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Laurence SlembrouckGiuseppe Floris
Aug 16, 2021·The Journal of Surgical Research·Mohammadreza TabaryAhmad Kaviani
Oct 23, 2018·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Roisin O'CearbhaillCecily M Quinn

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