Relevance of Regulatory T Cells during Colorectal Cancer Development

Cancers
Jonadab E OlguínLuis I Terrazas

Abstract

In recent years, there has been a significant increase in the study of own and foreign human factors favoring the development of different types of cancer, including genetic and environmental ones. However, the fact that the immune response plays a fundamental role in the development of immunity and susceptibility to colorectal cancer (CRC) is much stronger. Among the many cell populations of the immune system that participate in restricting or favoring CRC development, regulatory T cells (Treg) play a major role in orchestrating immunomodulation during CRC. In this review, we established concrete evidence supporting the fact that Treg cells have an important role in the promotion of tumor development during CRC, mediating an increasing suppressive capacity which controls the effector immune response, and generating protection for tumors. Furthermore, Treg cells go through a process called "phenotypic plasticity", where they co-express transcription factors that promote an inflammatory profile. We reunited evidence that describes the interaction between the different effector populations of the immune response and its modulation by Treg cells adapted to the tumor microenvironment, including the mechanisms used by Treg cells to ...Continue Reading

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Citations

Jan 9, 2021·Journal of Translational Medicine·Jungang LiuWeizhong Tang
May 1, 2021·International Journal of Molecular Sciences·Yael Delgado-RamirezSonia Leon-Cabrera
Nov 5, 2021·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Xanthi StachteaDaniel B Longley

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