PMID: 15383577Sep 24, 2004Paper

Relevance of the direct pathway of sensitization in corneal transplantation is dictated by the graft bed microenvironment

The Journal of Immunology : Official Journal of the American Association of Immunologists
Syed O HuqM Reza Dana

Abstract

Corneal grafts were until recently considered entirely devoid of resident APCs, giving rise to the tenet that alloantigen recognition is mediated exclusively by the indirect (host APC-dependent) pathway. The recent discovery of a resident myeloid corneal dendritic cell population that is normally MHC class II(-) but can readily up-regulate class II expression during inflammation led us to hypothesize that under certain conditions the direct pathway of allosensitization becomes operative. To test this, corneal allotransplants were performed in either inflamed (high-risk (HR)) or uninflamed (low-risk (LR)) host beds in mice, and the frequencies of host T cells activated via the direct pathway were determined. We found that directly primed CD4(+) T cells were detected in the HR but not LR setting, and these cells displayed a clear Th1 phenotype by 2 wk after grafting. Moreover, the use of MHC class II knockout donor tissue led to significantly enhanced survival of HR but not LR allografts. Finally, we show that donor corneal APC demonstrate high expression of CD40, CD80, and CD86 costimulatory molecules when derived from HR but not LR grafts. These data are the first to report that a functional donor APC-dependent direct response ...Continue Reading

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Citations

Mar 7, 2006·Seminars in Ophthalmology·M Reza Dana
Jan 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lucia KuffováJohn V Forrester
Aug 12, 2009·Acta Ophthalmologica·Uwe Pleyer, Stephan Schlickeiser
Feb 26, 2016·Transplantation·Thomas H DohlmanReza Dana
Dec 27, 2016·Frontiers in Immunology·Jose MarinoGilles Benichou
May 26, 2017·Mediators of Inflammation·Afsaneh Amouzegar, Sunil K Chauhan
Aug 22, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Mingshun LiSunil K Chauhan
Sep 25, 2018·Transplantation·Chunyi ShaoReza Dana
Aug 4, 2007·International Ophthalmology·Eva-Marie Chong, M Reza Dana
Jun 14, 2006·Transplantation·Clay BeauregardM Reza Dana
Dec 26, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sunil K ChauhanReza Dana
Mar 3, 2010·Immunological Reviews·John V ForresterPaul G McMenamin
Nov 26, 2010·Cornea·Hidetaka Hara, David K C Cooper
Sep 17, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel R SabanReza Dana
Feb 16, 2013·European Journal of Immunology·Gilles Benichou, Georges Tocco
May 18, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Afsaneh AmouzegarReza Dana
Jul 15, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Laura SchöllhornClaus Cursiefen
Oct 13, 2017·Cornea·Takenori InomataReza Dana
Jan 8, 2018·Cellular and Molecular Life Sciences : CMLS·Maryam TahvildariReza Dana
Oct 7, 2019·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Giulia CocoReza Dana
Feb 27, 2020·Journal of Clinical Medicine·Antonio Di ZazzoTakenori Inomata
May 19, 2010·Expert Review of Clinical Immunology·Thomas Ritter, Uwe Pleyer
Aug 2, 2012·Chimerism·William J Burlingham, Gilles Benichou
Jun 26, 2018·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kortney A RobinsonGilles Benichou
Oct 18, 2005·Cornea·Satoru YamagamiNobuyuki Ebihara
Feb 9, 2010·Current Eye Research·Ulrike M IrschickEveline U Irschick
Feb 13, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Andrea VitovaJohn V Forrester
Mar 16, 2011·Journal of Leukocyte Biology·Yihe ChenReza Dana
Oct 22, 2013·Seminars in Ophthalmology·Yureeda Qazi, Pedram Hamrah
Aug 4, 2018·Investigative Ophthalmology & Visual Science·Han WangMin Zhao
Jun 11, 2019·Stem Cells Translational Medicine·Sharad K MittalSunil K Chauhan
Nov 30, 2018·Investigative Ophthalmology & Visual Science·Maria J LopezPedram Hamrah
Sep 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Linling ShenM Reza Dana
Aug 14, 2021·International Ophthalmology·Merve Beyza Yıldız, Elvin Yıldız

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